Terrence R Jao1, Krishna S Nayak2. 1. Department of Biomedical Engineering, University of Southern California, Los Angeles, California, USA. 2. Ming Hsieh Department of Electrical Engineering, University of Southern California, Los Angeles, California, USA.
Abstract
PURPOSE: Transit delay is a potential source of error in cardiac arterial spin-labeled (ASL) in heart failure or with collateral circulation. This study demonstrates the feasibility of using transit delay insensitive velocity selective ASL and compares its performance with flow-sensitive alternating inversion recovery (FAIR) ASL. METHODS: Velocity selective labeling was achieved using an adiabatic BIR8 preparation. FAIR and velocity-selective ASL (VSASL) with various velocity cutoffs (VC = 10-40 cm/s) and labeling directions (anterior-posterior X, lateral-septal Y, and apical-basal Z) were carried out in 10 healthy volunteers (1F/9M age 23-30 y). Myocardial blood flow (MBF) and temporal signal-to-noise (TSNR) were measured. RESULTS: VSASL sensitivity to perfusion decreased with increasing VC . At low VC (<5 cm/s), spurious labeling of myocardium occurs and overestimates MBF. MBF measured with FAIR (1.12 ± 0.26 ml/g/min) and VASL (1.26 ± 0.27 ml/g/min) at VC of 10 cm/s in Z were comparable (TOST with difference of 0.30 ml/g/min, P = 0.049). TSNR was 2.8 times larger using FAIR (13.62 ± 5.25) than in VSASL (4.87 ± 1.58). VSASL was insensitive to perfusion in the Y direction. X and Z performed similarly with TSNR of 4.17 ± 2.32 and 3.97 ± 0.56, respectively. CONCLUSION: VSASL is a promising alternative to FAIR ASL in the heart and is well suited for scenarios when transit delays are long. Magn Reson Med 80:272-278, 2018.
PURPOSE: Transit delay is a potential source of error in cardiac arterial spin-labeled (ASL) in heart failure or with collateral circulation. This study demonstrates the feasibility of using transit delay insensitive velocity selective ASL and compares its performance with flow-sensitive alternating inversion recovery (FAIR) ASL. METHODS: Velocity selective labeling was achieved using an adiabatic BIR8 preparation. FAIR and velocity-selective ASL (VSASL) with various velocity cutoffs (VC = 10-40 cm/s) and labeling directions (anterior-posterior X, lateral-septal Y, and apical-basal Z) were carried out in 10 healthy volunteers (1F/9M age 23-30 y). Myocardial blood flow (MBF) and temporal signal-to-noise (TSNR) were measured. RESULTS: VSASL sensitivity to perfusion decreased with increasing VC . At low VC (<5 cm/s), spurious labeling of myocardium occurs and overestimates MBF. MBF measured with FAIR (1.12 ± 0.26 ml/g/min) and VASL (1.26 ± 0.27 ml/g/min) at VC of 10 cm/s in Z were comparable (TOST with difference of 0.30 ml/g/min, P = 0.049). TSNR was 2.8 times larger using FAIR (13.62 ± 5.25) than in VSASL (4.87 ± 1.58). VSASL was insensitive to perfusion in the Y direction. X and Z performed similarly with TSNR of 4.17 ± 2.32 and 3.97 ± 0.56, respectively. CONCLUSION: VSASL is a promising alternative to FAIR ASL in the heart and is well suited for scenarios when transit delays are long. Magn Reson Med 80:272-278, 2018.
Authors: Isabell K Bones; Suzanne L Franklin; Anita A Harteveld; Matthias J P van Osch; Sophie Schmid; Jeroen Hendrikse; Chrit Moonen; Marijn van Stralen; Clemens Bos Journal: Magn Reson Med Date: 2021-02-04 Impact factor: 4.668
Authors: Qin Qin; David C Alsop; Divya S Bolar; Luis Hernandez-Garcia; James Meakin; Dapeng Liu; Krishna S Nayak; Sophie Schmid; Matthias J P van Osch; Eric C Wong; Joseph G Woods; Greg Zaharchuk; Moss Y Zhao; Zungho Zun; Jia Guo Journal: Magn Reson Med Date: 2022-07-12 Impact factor: 3.737
Authors: Isabell K Bones; Suzanne L Franklin; Anita A Harteveld; Matthias J P van Osch; Jeroen Hendrikse; Chrit Moonen; Marijn van Stralen; Clemens Bos Journal: Magn Reson Med Date: 2020-03-17 Impact factor: 4.668