Literature DB >> 291063

Evaluation of a common receptor-complement concept for predicting the antileukemic activity of nucleosides.

L B Townsend, K H Schram, J Beránek.   

Abstract

The triangulation arrangement of one nitrogen and two oxygen atoms proposed as a requirement for antileukemic activity involving a "common receptor-complement feature" has been reevaluated specifically as it applies to nucleosides. This re-evaluation has resulted in a rejection of the "receptor-complement feature" as a working model for the a priori design of nucleosides as compounds active against leukemia L-1210.

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Year:  1979        PMID： 291063      PMCID： PMC383980          DOI： 10.1073/pnas.76.8.4075

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  11 in total

Review 1.  Incorporation of analog purine nucleosides into the formed elements of human blood: erythrocytes, platelets, and lymphocytes.

Authors:  R E Parks; G W Crabtree; C M Kong; R P Agarwal; K C Agarwal; E M Scholar
Journal:  Ann N Y Acad Sci       Date:  1975-08-08       Impact factor: 5.691

2.  Synthesis of 2-amino-5-cyano-7-(beta-D-ribofuranosyl)-pyrrolo[2,3-d]pyrimidin-4-one. An important precursor for the synthesis of nucleoside Q and Q.

Authors:  C S Cheng; B C Hinshaw; R P Panzica; L B Townsend
Journal:  J Am Chem Soc       Date:  1976-11-24       Impact factor: 15.419

3.  Inosine analogs as substrates for adenosine kinase--influence of ionization of the N-1 proton on the rate of phosphorylation.

Authors:  L L Bennet; D L Hill; P W Allan
Journal:  Biochem Pharmacol       Date:  1978-01-01       Impact factor: 5.858

4.  Specificity of adenosine deaminase inhibitors.

Authors:  J F Henderson; L Brox; G Zombor; D Hunting; C A Lomax
Journal:  Biochem Pharmacol       Date:  1977-11-01       Impact factor: 5.858

5.  Biochemical properties of the nucleoside of 3-amino-1,5-dihydro-5-methyl-1,4,5,6,8-pentaazaacenaphthylene (NSC-154020).

Authors:  L L Bennett; D Smithers; D L Hill; L M Rose; J A Alexander
Journal:  Biochem Pharmacol       Date:  1978-01-15       Impact factor: 5.858

6.  Adenosine analogs and human platelets--II. Inhibition of ADP-induced aggregation by carbocyclic adenosine and imidazole-ring modified analogs. Significance of alterations in the nucleotide pools.

Authors:  K C Agarwal; R E Parks; L B Townsend
Journal:  Biochem Pharmacol       Date:  1979       Impact factor: 5.858

7.  N-Methylformycins. Reactivity with adenosine deaminase, incorporation into intracellular nucleotides of human erythrocytes and L 1210 cells and cytotoxicity to L 1210 cells.

Authors:  G W Crabtree; R P Agarwal; R E Parks; A F Lewis; L L Wotring; L B Townsend
Journal:  Biochem Pharmacol       Date:  1979-05-01       Impact factor: 5.858

8.  Transport, phosphorylation, and toxicity of a tricyclic nucleoside in cultured Novikoff rat hepatoma cells and other cell lines and relase of its monophosphate by the cells.

Authors:  P G Plagemann
Journal:  J Natl Cancer Inst       Date:  1976-12       Impact factor: 13.506

9.  Comparative study by circular dichroism of the conformation of deazapurine nucleosides and that of common purine nucleosides.

Authors:  D W Miles; L B Townsend; P Redington; H Eyring
Journal:  Proc Natl Acad Sci U S A       Date:  1976-07       Impact factor: 11.205

10.  Synthesis, chemical reactivity, and chemotherapeutic activity of certain selenonucleosides and nucleosides related to the pyrrolo(2,3-d)pyrimidine nucleoside antibiotics.

Authors:  L B Townsend; G H Milne
Journal:  Ann N Y Acad Sci       Date:  1975-08-08       Impact factor: 5.691
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