Literature DB >> 29104891

Microglial Phagocytosis Assay.

Hong Lian1, Ethan Roy2, Hui Zheng2.   

Abstract

Phagocytosis is essential for microglial clearance of apoptotic cells, extracellular protein aggregates, and infectious bacteria in the central nervous system (CNS). While the preparation of primary microglial culture has been described elsewhere, this protocol describes the microglial phagocytosis experimental procedure and the subsequent measurement of microglial phagocytic ability using fluorescent latex beads or fluorescent amyloid beta 42 (Aβ42) peptides.

Entities:  

Year:  2016        PMID： 29104891      PMCID： PMC5669280          DOI： 10.21769/BioProtoc.1988

Source DB:  PubMed          Journal:  Bio Protoc        ISSN： 2331-8325


  6 in total

1.  Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner.

Authors:  Dorothy P Schafer; Emily K Lehrman; Amanda G Kautzman; Ryuta Koyama; Alan R Mardinly; Ryo Yamasaki; Richard M Ransohoff; Michael E Greenberg; Ben A Barres; Beth Stevens
Journal:  Neuron       Date:  2012-05-24       Impact factor: 17.173

Review 2.  Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases.

Authors:  Joshua A Smith; Arabinda Das; Swapan K Ray; Naren L Banik
Journal:  Brain Res Bull       Date:  2011-10-18       Impact factor: 4.077

Review 3.  Microglia and neurodegeneration: the role of systemic inflammation.

Authors:  Colm Cunningham
Journal:  Glia       Date:  2012-06-06       Impact factor: 7.452

Review 4.  Innate immune activation in neurodegenerative disease.

Authors:  Michael T Heneka; Markus P Kummer; Eicke Latz
Journal:  Nat Rev Immunol       Date:  2014-07       Impact factor: 53.106

5.  Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease.

Authors:  Hong Lian; Alexandra Litvinchuk; Angie C-A Chiang; Nadia Aithmitti; Joanna L Jankowsky; Hui Zheng
Journal:  J Neurosci       Date:  2016-01-13       Impact factor: 6.167

Review 6.  Phagocytosis of microglia in the central nervous system diseases.

Authors:  Ruying Fu; Qingyu Shen; Pengfei Xu; Jin Jun Luo; Yamei Tang
Journal:  Mol Neurobiol       Date:  2014-01-07       Impact factor: 5.590
  6 in total
  11 in total

1.  TREM2 is thyroid hormone regulated making the TREM2 pathway druggable with ligands for thyroid hormone receptor.

Authors:  Skylar J Ferrara; Priya Chaudhary; Margaret J DeBell; Gail Marracci; Hannah Miller; Evan Calkins; Edvinas Pocius; Brooke A Napier; Ben Emery; Dennis Bourdette; Thomas S Scanlan
Journal:  Cell Chem Biol       Date:  2021-08-09       Impact factor: 8.116

2.  Targeting NLRP3 signaling by a novel-designed sulfonylurea compound for inhibition of microglial inflammation.

Authors:  Changwen Zhang; Ayyiliath M Sajith; Xiaotian Xu; Jianxiong Jiang; J Phillip Bowen; Amol Kulkarni; Jiukuan Hao
Journal:  Bioorg Med Chem       Date:  2022-01-31       Impact factor: 3.641

3.  Characterization of IMG Microglial Cell Line as a Valuable In Vitro Tool for NLRP3 Inflammasome Studies.

Authors:  Janeli Viil; Kelli Somelar-Duracz; Külli Jaako; Kaili Anier; Alexander Zharkovsky
Journal:  Cell Mol Neurobiol       Date:  2022-09-26       Impact factor: 4.231

4.  Neonatal exposure to organophosphorus flame retardant TDCPP elicits neurotoxicity in mouse hippocampus via microglia-mediated inflammation in vivo and in vitro.

Authors:  Xiali Zhong; Jingwei Wu; Weijian Ke; Yuejin Yu; Di Ji; Jianmeng Kang; Jiahuang Qiu; Can Wang; Panpan Yu; Yanhong Wei
Journal:  Arch Toxicol       Date:  2020-01-01       Impact factor: 5.153

5.  A Rigorous Quantitative Approach to Analyzing Phagocytosis Assays.

Authors:  Michael D Caponegro; Kaitlyn Koenig Thompson; Maryam Tayyab; Stella E Tsirka
Journal:  Bio Protoc       Date:  2020-08-05

Review 6.  Autophagy & Phagocytosis in Neurological Disorders and their Possible Cross-talk.

Authors:  Gaigai Li; Prativa Sherchan; Zhouping Tang; Jiping Tang
Journal:  Curr Neuropharmacol       Date:  2021       Impact factor: 7.708

Review 7.  Phagocytosis in the Brain: Homeostasis and Disease.

Authors:  Dylan A Galloway; Alexandra E M Phillips; David R J Owen; Craig S Moore
Journal:  Front Immunol       Date:  2019-04-16       Impact factor: 7.561

8.  MicroRNA-100-5p and microRNA-298-5p released from apoptotic cortical neurons are endogenous Toll-like receptor 7/8 ligands that contribute to neurodegeneration.

Authors:  Thomas Wallach; Zoé J Mossmann; Michal Szczepek; Max Wetzel; Rui Machado; Martin Raden; Milad Miladi; Gunnar Kleinau; Christina Krüger; Paul Dembny; Drew Adler; Yuanyuan Zhai; Victor Kumbol; Omar Dzaye; Jutta Schüler; Matthias Futschik; Rolf Backofen; Patrick Scheerer; Seija Lehnardt
Journal:  Mol Neurodegener       Date:  2021-11-27       Impact factor: 14.195

9.  Sequence-specific extracellular microRNAs activate TLR7 and induce cytokine secretion and leukocyte migration.

Authors:  Niming Wu; Brenda M Morsey; Katy M Emanuel; Howard S Fox
Journal:  Mol Cell Biochem       Date:  2021-07-27       Impact factor: 3.396

10.  Decreased neutrophil levels in mice with traumatic brain injury after cape administration.

Authors:  Rizha Anshori Nasution; Andi Asadul Islam; Mochammad Hatta
Journal:  Ann Med Surg (Lond)       Date:  2020-05-04
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