Bojan Vulovic1, Donald A Watson1. 1. Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA, dawatson@udel.edu.
Abstract
Since the discovery of the Heck reaction in the early seventies, this reaction has become a powerful tool in synthetic organic chemistry. By employing heteroatomic instead of traditional carbon electrophiles, the Heck reaction shows an intriguing flexibility. These "hetereoatomic-Heck reactions" reinvigorate the area, offering new routes to highly useful synthetic precursors and structural motifs present in biologically active compounds. This microreview focuses on early developments leading to the heteroatomic-Heck reactions (silyl-Heck, boryl-Heck and intramolecular aza-Heck), current state of the emerging area, as well as that of a few related processes.
class="Chemical">Siclass="Chemical">nce the discovery of the class="Chemical">n class="Chemical">Heck reaction in the early seventies, this reaction has become a powerful tool in synthetic organic chemistry. By employing heteroatomic instead of traditional carbon electrophiles, the Heck reaction shows an intriguing flexibility. These "hetereoatomic-Heck reactions" reinvigorate the area, offering new routes to highly useful synthetic precursors and structural motifs present in biologically active compounds. This microreview focuses on early developments leading to the heteroatomic-Heck reactions (silyl-Heck, boryl-Heck and intramolecularaza-Heck), current state of the emerging area, as well as that of a few related processes.
Authors: Carin C C Johansson Seechurn; Matthew O Kitching; Thomas J Colacot; Victor Snieckus Journal: Angew Chem Int Ed Engl Date: 2012-05-09 Impact factor: 15.336
Authors: Jesse R McAtee; Sara E S Martin; Derek T Ahneman; Keywan A Johnson; Donald A Watson Journal: Angew Chem Int Ed Engl Date: 2012-03-01 Impact factor: 15.336