Literature DB >> 29104302

Fluorescent Probes and Labels for Cellular Imaging.

Christoph J Fahrni.   

Abstract

Metal-responsive fluorescent indicators are powerful tools for visualizing trace metals with subcellular resolution. By taking advantage of the diverse photophysical properties of organic fluorophores, metal ion-selective fluorescent indicators have been rationally designed and tailored towards cellular applications. This review summarizes challenges associated with the probe design and describes recent efforts in our research group in developing selective and sensitive reagents for the detection of zinc and copper in mammalian cells.

Entities:  

Keywords:  excited state proton transfer; imaging; photoinduced electron transfer; trace metals; x-ray fluorescence microscopy

Year:  2009        PMID： 29104302      PMCID： PMC5667356          DOI： 10.2533/chimia.2009.714

Source DB:  PubMed          Journal:  Chimia (Aarau)        ISSN： 0009-4293            Impact factor:   1.509


  22 in total

1.  A fluorogenic probe for the copper(I)-catalyzed azide-alkyne ligation reaction: modulation of the fluorescence emission via 3(n,pi)-1(pi,pi) inversion.

Authors:  Zhen Zhou; Christoph J Fahrni
Journal:  J Am Chem Soc       Date:  2004-07-28       Impact factor: 15.419

2.  Imaging dynamic redox changes in mammalian cells with green fluorescent protein indicators.

Authors:  Colette T Dooley; Timothy M Dore; George T Hanson; W Coyt Jackson; S James Remington; Roger Y Tsien
Journal:  J Biol Chem       Date:  2004-02-25       Impact factor: 5.157

Review 3.  Zinc transporters and the cellular trafficking of zinc.

Authors:  David J Eide
Journal:  Biochim Biophys Acta       Date:  2006-04-18

Review 4.  Biological applications of X-ray fluorescence microscopy: exploring the subcellular topography and speciation of transition metals.

Authors:  Christoph J Fahrni
Journal:  Curr Opin Chem Biol       Date:  2007-03-13       Impact factor: 8.822

5.  Excited-state intramolecular proton transfer in 2-(2'-arylsulfonamidophenyl)benzimidazole derivatives: the effect of donor and acceptor substituents.

Authors:  Maged M Henary; Yonggang Wu; John Cody; S Sumalekshmy; Jing Li; Subrata Mandal; Christoph J Fahrni
Journal:  J Org Chem       Date:  2007-05-25       Impact factor: 4.354

Review 6.  Synthetic fluorescent sensors for studying the cell biology of metals.

Authors:  Dylan W Domaille; Emily L Que; Christopher J Chang
Journal:  Nat Chem Biol       Date:  2008-03       Impact factor: 15.040

7.  Design of emission ratiometric metal-ion sensors with enhanced two-photon cross section and brightness.

Authors:  S Sumalekshmy; Maged M Henary; Nisan Siegel; Padreyia V Lawson; Yonggang Wu; Karin Schmidt; Jean-Luc Brédas; Joseph W Perry; Christoph J Fahrni
Journal:  J Am Chem Soc       Date:  2007-09-11       Impact factor: 15.419

8.  Imaging of the intracellular topography of copper with a fluorescent sensor and by synchrotron x-ray fluorescence microscopy.

Authors:  Liuchun Yang; Reagan McRae; Maged M Henary; Raxit Patel; Barry Lai; Stefan Vogt; Christoph J Fahrni
Journal:  Proc Natl Acad Sci U S A       Date:  2005-08-01       Impact factor: 11.205

9.  Differential tuning of the electron transfer parameters in 1,3,5-triarylpyrazolines: a rational design approach for optimizing the contrast ratio of fluorescent probes.

Authors:  John Cody; Subrata Mandal; Liuchun Yang; Christoph J Fahrni
Journal:  J Am Chem Soc       Date:  2008-09-04       Impact factor: 15.419

Review 10.  Mechanisms for copper acquisition, distribution and regulation.

Authors:  Byung-Eun Kim; Tracy Nevitt; Dennis J Thiele
Journal:  Nat Chem Biol       Date:  2008-03       Impact factor: 15.040
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