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Literature DB >> 291039

The smallest genome RNA segment of influenza virus contains two genes that may overlap.

S C Inglis, T Barrett, C M Brown, J W Almond.

Abstract

The genome of influenza virus consists of eight segments of single-stranded RNA, each of which encodes a different polypeptide. In addition to the eight recognized gene products, the virus specifies a distinct smaller nonstructural polypeptide (NS2), which is translated from a separate species of virus-specific mRNA. The location on the virus genome of the gene encoding this polypeptide was investigated by hybridization of the NS2 mRNA with isolated subgenomic RNA species, and by correlation of the inheritance of a strain-specific NS2 with inheritance of particular genome RNA segments during recombination between two different virus strains. The genetic information for NS2 was found to reside in the smallest genome RNA segment of the virion, which also encodes the NS1 polypeptide. Considering the sizes of the molecules involved, it is likely that the coding sequences for the two polypeptides overlap.

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Year: 1979 PMID： 291039 PMCID： PMC383920 DOI： 10.1073/pnas.76.8.3790

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

31 in total

1. Synthesis of influenza virus proteins in infected cells: translation of viral polypeptides, including three P polypeptides, from RNA produced by primary transcription.

Authors: R A Lamb; P W Choppin
Journal: Virology Date: 1976-10-15 Impact factor: 3.616

2. Correlation between RNA fragments of fowl plague virus and their corresponding gene functions.

Authors: C Scholtissek; E Harms; W Rohde; M Orlich; R Rott
Journal: Virology Date: 1976-10-15 Impact factor: 3.616

3. Polypeptides specified by the influenza virus genome I. Evidence for eight distinct gene products specified by fowl plague virus.

Authors: S C Inglis; A R Carroll; R A Lamb; B W Mahy
Journal: Virology Date: 1976-10-15 Impact factor: 3.616

4. Polypeptides specified by the influenza virus genome. 3. Control of synthesis in infected cells.

Authors: S C Inglis; B W Mahy
Journal: Virology Date: 1979-05 Impact factor: 3.616

5. Transfer of 5'-terminal cap of globin mRNA to influenza viral complementary RNA during transcription in vitro.

Authors: S J Plotch; M Bouloy; R M Krug
Journal: Proc Natl Acad Sci U S A Date: 1979-04 Impact factor: 11.205

6. Genetic recombination between two strains of fowl plague virus: construction of genetic maps.

Authors: J W Almond; R D Barry
Journal: Virology Date: 1979-01-30 Impact factor: 3.616

7. Temperature-sensitive mutants of fowl plague virus: isolation and genetic characterization.

Authors: J W Almond; D McGeoch; R D Barry
Journal: Virology Date: 1979-01-30 Impact factor: 3.616

8. Evidence for a ninth influenza viral polypeptide.

Authors: R A Lamb; P R Etkind; P W Choppin
Journal: Virology Date: 1978-11 Impact factor: 3.616

9. A single gene determines the host range of influenza virus.

Authors: J W Almond
Journal: Nature Date: 1977-12-15 Impact factor: 49.962

10. Nucleotide sequences at the 5' termini of influenza virus RNAs and their transcripts.

Authors: J J Skehel; A J Hay
Journal: Nucleic Acids Res Date: 1978-04 Impact factor: 16.971

47 in total

1. Phylogenetic analysis of the non-structural (NS) gene of influenza A viruses isolated in Kazakhstan in 2002-2009.

Authors: Andrey Bogoyavlenskiy; Vladimir Berezin; Alexey Prilipov; Ilya Korotetskiy; Irina Zaitseva; Aydyn Kydyrmanov; Kobey Karamedin; Nailya Ishmukhametova; Saule Asanova; Marat Sayatov; Kainar Zhumatov
Journal: Virol Sin Date: 2011-12-10 Impact factor: 4.327

2. Genetic analysis of influenza virus NS1 gene: a temperature-sensitive mutant shows defective formation of virus particles.

Authors: Urtzi Garaigorta; Ana M Falcón; Juan Ortín
Journal: J Virol Date: 2005-12 Impact factor: 5.103

3. Structure-based design of NS2 mutants for attenuated influenza A virus vaccines.

Authors: Hatice Akarsu; Kiyoko Iwatsuki-Horimoto; Takeshi Noda; Eiryo Kawakami; Hiroaki Katsura; Florence Baudin; Taisuke Horimoto; Yoshihiro Kawaoka
Journal: Virus Res Date: 2010-10-21 Impact factor: 3.303

Review 4. Diversity of coding strategies in influenza viruses.

Authors: R A Lamb; C M Horvath
Journal: Trends Genet Date: 1991-08 Impact factor: 11.639

5. Mapping of the two overlapping genes for polypeptides NS1 and NS2 on RNA segment 8 of influenza virus genome.

Authors: R A Lamb; P W Choppin; R M Chanock; C J Lai
Journal: Proc Natl Acad Sci U S A Date: 1980-04 Impact factor: 11.205

6. Mutation in NS2, a nonstructural protein of influenza A virus, extragenically causes aberrant replication and expression of the PA gene and leads to generation of defective interfering particles.

Authors: T Odagiri; K Tobita
Journal: Proc Natl Acad Sci U S A Date: 1990-08 Impact factor: 11.205

7. The N-terminal half of the influenza virus NS1 protein is sufficient for nuclear retention of mRNA and enhancement of viral mRNA translation.

Authors: R M Marión; T Aragón; A Beloso; A Nieto; J Ortín
Journal: Nucleic Acids Res Date: 1997-11-01 Impact factor: 16.971