Miguel A Patino1, Rafael E Ramirez1, Carlos A Perez1, Lei Feng2, Pranav Kataria3, Jeffrey Myers3, Juan P Cata4. 1. Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Anesthesiology and Surgical Oncology Research Group, Houston, TX, USA. 2. Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. 3. Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. 4. Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Anesthesiology and Surgical Oncology Research Group, Houston, TX, USA. Electronic address: jcata@mdanderson.org.
Abstract
OBJECTIVES: To investigate the impact of opioid use on cancer recurrence after oral cancer surgery. We hypothesized that the amount of opioids administered during oral cancer surgery is an independent predictor of recurrence free survival (RFS) and overall survival (OS). METHODS: After Institutional Review Board approval, we collected demographic, tumor related, intraoperative and survival data of patients who had oral cancer surgery. Multivariable Cox proportional hazards models were used to determine the impact of important covariates on RFS and OS. RESULTS: 268 patients were included. After adjusting for significant covariates, the amount of opioids administered during surgery was not an independent predictor of RFS (HR: 1.27 [CI 95%, 0.838-1.924], p=0.26). However, we observed an association between opioid consumption and shorter OS (HR=1.77, [CI 95%=0.995-3.149]. p=0.05). CONCLUSIONS: High requirements of opioids during surgery increase the risk of recurrence and mortality by 27% and 77%, although the association is not statically significant.
OBJECTIVES: To investigate the impact of opioid use on cancer recurrence after oral cancer surgery. We hypothesized that the amount of opioids administered during oral cancer surgery is an independent predictor of recurrence free survival (RFS) and overall survival (OS). METHODS: After Institutional Review Board approval, we collected demographic, tumor related, intraoperative and survival data of patients who had oral cancer surgery. Multivariable Cox proportional hazards models were used to determine the impact of important covariates on RFS and OS. RESULTS: 268 patients were included. After adjusting for significant covariates, the amount of opioids administered during surgery was not an independent predictor of RFS (HR: 1.27 [CI 95%, 0.838-1.924], p=0.26). However, we observed an association between opioid consumption and shorter OS (HR=1.77, [CI 95%=0.995-3.149]. p=0.05). CONCLUSIONS: High requirements of opioids during surgery increase the risk of recurrence and mortality by 27% and 77%, although the association is not statically significant.
Authors: Jianqi Zheng; Hengrui Liang; Runchen Wang; Ran Zhong; Shunjun Jiang; Wei Wang; Yi Zhao; Zhuxing Chen; Wenhua Liang; Jun Liu; Jianxing He Journal: Transl Lung Cancer Res Date: 2021-10
Authors: Jadie Plücker; Naita M Wirsik; Alina S Ritter; Thomas Schmidt; Markus A Weigand Journal: Langenbecks Arch Surg Date: 2021-02-01 Impact factor: 3.445