| Literature DB >> 29103141 |
Feng Li1, Wenqiang Guo1, Li Wu1, Tianjiao Zhu1, Qianqun Gu1, Dehai Li1,2, Qian Che3.
Abstract
Three new diketopiperazine derivatives (DKPs), saroclazines A-C (1-3) along with three known DKPs (4-6) were isolated from mangrove-derived fungi Sarocladium kiliense HDN11-84. Saroclazines A-B (1 and 2) possessed a free amide structure, which was first found in sulfur-containing aromatic DKPs. Their structures were elucidated by NMR, HRESIMS and X-ray. The cytotoxic activity of new compounds (1-3) was tested against HeLa cell lines, among which compound 2 showed an IC50 value of 4.2 µM.Entities:
Keywords: Cytotoxic activity; Fungi; Mangrove; Sarocladium kiliense
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Year: 2017 PMID： 29103141 DOI： 10.1007/s12272-017-0961-7
Source DB: PubMed Journal: Arch Pharm Res ISSN： 0253-6269 Impact factor: 4.946