Sho Sawazaki1, Takashi Oshima2, Kentaro Sakamaki3, Toru Aoyama1, Tsutomu Sato1, Manabu Shiozawa4, Takaki Yoshikawa4, Yasushi Rino1, Toshio Imada5, Munetaka Masuda1. 1. Department of Surgery, Yokohama City University, Yokohama, Japan. 2. Department of Surgery, Yokohama City University, Yokohama, Japan ohshimatakashi@yahoo.co.jp. 3. Department of Biostatistics, Yokohama City University Medical Center, Yokohama, Japan. 4. Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan. 5. Department of Surgery, Saiseikai Yokohama-shi Nanbu Hospital, Yokohama, Japan.
Abstract
BACKGROUND: Overall survival remains unsatisfactory in stage II/III gastric cancer, even after curative resection and adjuvant chemotherapy. Tensin 4 (TNS4), a cell adhesion factor, is associated with cancer-cell motility and migration. PATIENTS AND METHODS: We examined the clinical significance of TNS4 gene expression in 134 patients with stage II/III gastric cancer who underwent adjuvant chemotherapy with S-1. TNS4 gene expression in surgical specimens was measured by quantitative reverse-transcription polymerase chain reaction (RT-PCR). RESULTS: TNS4 gene expression levels were significantly higher in cancer tissue than in adjacent normal mucosa. High TNS4 gene expression was associated with significantly poorer 5-year overall survival than was low expression. On multivariate analysis, TNS4 gene expression was an independent prognostic factor. CONCLUSION: Overexpression of the TNS4 gene is a useful independent predictor of outcomes in patients with stage II/III gastric cancer who undergo surgery and receive adjuvant chemotherapy with S-1. Copyright
BACKGROUND: Overall survival remains unsatisfactory in stage II/III gastric cancer, even after curative resection and adjuvant chemotherapy. Tensin 4 (TNS4), a cell adhesion factor, is associated with cancer-cell motility and migration. PATIENTS AND METHODS: We examined the clinical significance of TNS4 gene expression in 134 patients with stage II/III gastric cancer who underwent adjuvant chemotherapy with S-1. TNS4 gene expression in surgical specimens was measured by quantitative reverse-transcription polymerase chain reaction (RT-PCR). RESULTS:TNS4 gene expression levels were significantly higher in cancer tissue than in adjacent normal mucosa. High TNS4 gene expression was associated with significantly poorer 5-year overall survival than was low expression. On multivariate analysis, TNS4 gene expression was an independent prognostic factor. CONCLUSION: Overexpression of the TNS4 gene is a useful independent predictor of outcomes in patients with stage II/III gastric cancer who undergo surgery and receive adjuvant chemotherapy with S-1. Copyright
Authors: A Albasri; S Al-Ghamdi; W Fadhil; M Aleskandarany; Y-C Liao; D Jackson; D N Lobo; S H Lo; R Kumari; L Durrant; S Watson; K B Kindle; M Ilyas Journal: Oncogene Date: 2011-02-21 Impact factor: 9.867
Authors: Saleh Al-Ghamdi; Abdulkader Albasri; Julien Cachat; Salih Ibrahem; Belal A Muhammad; Darryl Jackson; Abdolrahman S Nateri; Karin B Kindle; Mohammad Ilyas Journal: PLoS One Date: 2011-06-16 Impact factor: 3.240