Bergenia ciliata: A comprehensive review of its traditional uses, phytochemistry, pharmacology and safety.

Bergenia ciliata is a medicinal plant used for the treatment of kidney stones. The presented review is the first attempt to gather utmost information about the distribution, ethno-medicines, phytochemical analysis, pharmacology and toxicology of B. ciliata. This review was designed with the aim to compile fragmented information about B. ciliata in addition to explore its therapeutic potential and future research opportunities. A total of 185 research papers were reviewed using several data sources such as; Web of Science, Scopus, Google scholar, Science direct and PubMed. Results of this review revealed that B. ciliata is being used to cure 104 different types of ailments. Although among reported disorders B. ciliata showed high potential in the treatment of gastrointestinal disorders but it is well known for the treatment of kidney disorders particularly kidney stones. Literature review showed that traditional healers mostly utilize it in powder form. Moreover, B. ciliata was reported to possess high antifungal, antiviral, anti plasmodial and antibacterial activities. Pharmacological studies reported that it has good antioxidant, anti-inflammatory, anti-tussive, anti-ulcer and anti-neoplastic activities. Variety of secondary metabolites belonging to different classes of compounds such as phenols, alcohols, terpenoids and fatty acid were reportedly isolated from B. ciliata. In spite of having better efficiency of ethno medicines and good pharmacological potential, B. ciliata has also shown toxic effects on living system in several studies. We invite the attention of researchers to carry out detailed ethno-pharmacological and toxicological studies on this valuable plant species in order to provide reliable knowledge to the patients and discover more novel compounds for the development of new drugs with fewer side effects on the living system as compare to modern medicines.