Edgar Carnero Contentti1, Néstor David Genco2, Javier Pablo Hryb3, Mercedes Caspi4, Edson Chiganer5, José Luis Di Pace3, Pablo Adrián López6, Carmen Lessa5, Alejandro Caride6, Mónica Perassolo3. 1. Section of Neurology, Hospital Carlos G. Durand, Buenos Aires, Argentina; Department of Neuroscience, Neuroimmunology Unit, Hospital Alemán, Buenos Aires, Argentina. Electronic address: junior.carnero@hotmail.com. 2. Neurology Service, Hospital Lagomaggiore, Mendoza, Argentina. 3. Section of Neurology, Hospital Carlos G. Durand, Buenos Aires, Argentina. 4. Neuroradiology Service, Fundación Escuela de Medicina Nuclear de Mendoza, Mendoza, Argentina. 5. Inmunology and Histocompatibility Unit, Hospital Carlos G. Durand, Buenos Aires, Argentina. 6. Department of Neuroscience, Neuroimmunology Unit, Hospital Alemán, Buenos Aires, Argentina.
Abstract
OBJECTIVE: To report the impact of multiple sclerosis (MS) on patients' quality of life (QoL) compared to systemic lupus erythematosus (SLE) using the 36-Item Short Form (SF-36) health questionnaire in Argentina. PATIENTS AND METHODS: Cross-sectional study. All consecutive MS patients, SLE and healthy controls (HC) were included. Demographics, clinical and radiological aspects, EDSS and SF-36 were assessed. RESULTS: A total of 191 subjects were included (MS=74, SLE=30 and HC=87). When we compared, using 2 standard deviations below the normal mean, the SF-36 subscales scores between MS and SLE, we found that MS patients experienced significant deterioration in general health (p<0.0001), vitality (p=0.009), current health (p<0.0001) and previous year health perception (p=0.003). Additional evaluated areas did not show significant differences. MS patients scored significantly lower in all categories compared to HC, except for bodily pain. An inverse correlation between EDSS and SF-36 total (R2=0.59, β -11.08, p<0.0001) and subscale scores was observed after applying regression analysis. CONCLUSION: MS behaves as a systemic disease from the functional point of view. Patient-reported QoL scales scores provide comprehensive additional prognostic information beyond the EDSS score. Therefore, adding the SF-36 questionnaire in clinical practice might be useful for the assessment and follow-up of MS patients.
OBJECTIVE: To report the impact of multiple sclerosis (MS) on patients' quality of life (QoL) compared to systemic lupus erythematosus (SLE) using the 36-Item Short Form (SF-36) health questionnaire in Argentina. PATIENTS AND METHODS: Cross-sectional study. All consecutive MSpatients, SLE and healthy controls (HC) were included. Demographics, clinical and radiological aspects, EDSS and SF-36 were assessed. RESULTS: A total of 191 subjects were included (MS=74, SLE=30 and HC=87). When we compared, using 2 standard deviations below the normal mean, the SF-36 subscales scores between MS and SLE, we found that MSpatients experienced significant deterioration in general health (p<0.0001), vitality (p=0.009), current health (p<0.0001) and previous year health perception (p=0.003). Additional evaluated areas did not show significant differences. MSpatients scored significantly lower in all categories compared to HC, except for bodily pain. An inverse correlation between EDSS and SF-36 total (R2=0.59, β -11.08, p<0.0001) and subscale scores was observed after applying regression analysis. CONCLUSION:MS behaves as a systemic disease from the functional point of view. Patient-reported QoL scales scores provide comprehensive additional prognostic information beyond the EDSS score. Therefore, adding the SF-36 questionnaire in clinical practice might be useful for the assessment and follow-up of MSpatients.
Authors: Katherine A Koenig; Erik B Beall; Ken E Sakaie; Daniel Ontaneda; Lael Stone; Stephen M Rao; Kunio Nakamura; Stephen E Jones; Mark J Lowe Journal: PLoS One Date: 2021-06-08 Impact factor: 3.240