Emilie Leclerc1, Rodrigo B Mansur2, Rodrigo Grassi-Oliveira3, Quirino Cordeiro4, Flavio Kapczinski5, Roger S McIntyre6, Elisa Brietzke7. 1. Research Group of Molecular and Behavioral Neuroscience of Bipolar Disorder, Department of Psychiatry, Federal University of São Paulo (Unifesp), São Paulo, SP, Brazil; Post-Graduation Program in Psychiatry and Medical Psychology, Federal University of São Paulo (Unifesp), São Paulo, SP, Brazil. 2. Mood Disorders Psychopharmacology Unit (MDPU), University Health Network (UHN), Toronto, ON, Canada. 3. Developmental Cognitive Neuroscience Laboratory (DCNL), Brain Institute (InsCer), Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil. 4. Santa Casa School of Medical Sciences of São Paulo, São Paulo, Brazil. 5. Brain and Cognition Discovery Foundation (BCDF), Toronto, ON, Canada. 6. Mood Disorders Psychopharmacology Unit (MDPU), University Health Network (UHN), Toronto, ON, Canada; Brain and Cognition Discovery Foundation (BCDF), Toronto, ON, Canada. 7. Research Group of Molecular and Behavioral Neuroscience of Bipolar Disorder, Department of Psychiatry, Federal University of São Paulo (Unifesp), São Paulo, SP, Brazil; Post-Graduation Program in Psychiatry and Medical Psychology, Federal University of São Paulo (Unifesp), São Paulo, SP, Brazil; Mood Disorders Psychopharmacology Unit (MDPU), University Health Network (UHN), Toronto, ON, Canada. Electronic address: elisabrietzke@hotmail.com.
Abstract
BACKGROUND: History of distal stressors such as childhood trauma is a well-established, non-specific vulnerability factor for multiple mental illnesses. The objective of this study was to investigate the possible association between history of childhood trauma and body mass index (BMI) in individuals in early and late stages of bipolar disorder (BD) and to verify is there was any difference in the association of sexual abuse history and obesity in early versus late stages of BD. METHODS: Seventy-one euthymic BD-type I patients and eighty-one healthy controls were evaluated using the Childhood Trauma Questionnaire (CTQ) and body mass index (BMI). The association between BMI and CTQ total and subscores were evaluated dividing BD population in early-stage BD-I (less than 10 years since onset of disease) or late-stage BD (more than 10 years). RESULTS: BD individuals had higher rates of history of childhood trauma than HC, especially sexual and emotional abuse, after adjusting for confounders. We observed a moderating effect of group on the association between BMI and sexual abuse (SA), but not on other modalities of childhood trauma, after adjustments for age, gender, ethnicity, education, alcohol and tobacco use. LIMITATIONS: Our sample included a predominance of female individuals. The study cross-sectional design does not allow concluding a cause-effect relationship. In dividing the BD subgroups in relation with the time since the onset, we supposed that the natural course of BD is linear. The CTQ is subject to recall bias. CONCLUSION: There is a relationship between childhood sexual abuse and BMI, but the direction of the association varies across the different stages of BD-I.
BACKGROUND: History of distal stressors such as childhood trauma is a well-established, non-specific vulnerability factor for multiple mental illnesses. The objective of this study was to investigate the possible association between history of childhood trauma and body mass index (BMI) in individuals in early and late stages of bipolar disorder (BD) and to verify is there was any difference in the association of sexual abuse history and obesity in early versus late stages of BD. METHODS: Seventy-one euthymic BD-type I patients and eighty-one healthy controls were evaluated using the Childhood Trauma Questionnaire (CTQ) and body mass index (BMI). The association between BMI and CTQ total and subscores were evaluated dividing BD population in early-stage BD-I (less than 10 years since onset of disease) or late-stage BD (more than 10 years). RESULTS: BD individuals had higher rates of history of childhood trauma than HC, especially sexual and emotional abuse, after adjusting for confounders. We observed a moderating effect of group on the association between BMI and sexual abuse (SA), but not on other modalities of childhood trauma, after adjustments for age, gender, ethnicity, education, alcohol and tobacco use. LIMITATIONS: Our sample included a predominance of female individuals. The study cross-sectional design does not allow concluding a cause-effect relationship. In dividing the BD subgroups in relation with the time since the onset, we supposed that the natural course of BD is linear. The CTQ is subject to recall bias. CONCLUSION: There is a relationship between childhood sexual abuse and BMI, but the direction of the association varies across the different stages of BD-I.
Authors: Maria Andreu Pascual; Jessica C Levenson; John Merranko; Mary Kay Gill; Heather Hower; Shirley Yen; Michael Strober; Tina R Goldstein; Benjamin I Goldstein; Neal D Ryan; Lauren M Weinstock; Martin B Keller; David Axelson; Boris Birmaher Journal: J Affect Disord Date: 2020-05-22 Impact factor: 4.839
Authors: Kai F Fischer; Maria S Simon; Julie Elsner; Johanna Dobmeier; Johannes Dorr; Leonie Blei; Peter Zill; Michael Obermeier; Richard Musil Journal: Eur Arch Psychiatry Clin Neurosci Date: 2021-03-17 Impact factor: 5.270