Marcelo Q Hoexter1, Claudinei E Biazoli2, Pedro G Alvarenga3, Marcelo C Batistuzzo3, Giovanni A Salum4, Ary Gadelha5, Pedro M Pan5, Mauricio Anés6, Leticia Mancini-Martins2, Luciana M Moura7, Carles Soriano-Mas8, Marco A G Del' Aquilla5, Edson Amaro9, Luis A Rohde4, Andrea P Jackowski5, Rodrigo A Bressan5, Euripedes C Miguel3, Maria C do Rosario10, João R Sato7. 1. Departamento e Instituto de Psiquiatria, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, SP, Brazil; National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, São Paulo, Brazil; Interdisciplinary Lab for Clinical Neurosciences (LiNC), Universidade Federal De Sao Paulo (UNIFESP), Sao Paulo, Brazil. Electronic address: mqhoexter@gmail.com. 2. Center of Mathematics, Computing and Cognition, Universidade Federal Do ABC, Santo Andre, Brazil. 3. Departamento e Instituto de Psiquiatria, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, SP, Brazil; National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, São Paulo, Brazil. 4. National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, São Paulo, Brazil; Department of Psychiatry, Federal University of Rio Grande Do Sul, Porto Alegre, Brazil. 5. National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, São Paulo, Brazil; Interdisciplinary Lab for Clinical Neurosciences (LiNC), Universidade Federal De Sao Paulo (UNIFESP), Sao Paulo, Brazil. 6. National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, São Paulo, Brazil; Department of Psychiatry, Federal University of Rio Grande Do Sul, Porto Alegre, Brazil; Medical Physics and Radioprotection Service, Hospital de Clínicas de Porto Alegre, Brazil. 7. National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, São Paulo, Brazil; Center of Mathematics, Computing and Cognition, Universidade Federal Do ABC, Santo Andre, Brazil. 8. Department of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL) and CIBERSAM, Carlos III Health Institute, Barcelona, Spain; Department of Psychobiology and Methodology of Health Sciences, Universitat Autònoma de Barcelona, Spain. 9. Department of Radiology, School of Medicine, University of Sao Paulo, São Paulo, Brazil. 10. National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, São Paulo, Brazil; Child and Adolescent Psychiatry Unit (UPIA) at the Department of Psychiatry, Federal University of São Paulo (UNIFESP), Sao Paulo, Brazil.
Abstract
BACKGROUND: The present study was designed to explore alterations in brain dynamics at rest that are associated with Obsessive Compulsive Symptoms (OCS) in childhood by measuring low frequency fluctuation of spontaneous brain activity in a large school community sample from a developing country. METHOD: Resting state functional magnetic resonance imaging data were collected in a sample of 655 children and adolescents (6-15 years old) from the brazilian 'High Risk Cohort Study for Psychiatric Disorders (HRC)'. OCS were assessed using items from the Compulsion and Obsessions section of the Development and Well-Being Assessment (DAWBA). The correlation between the fractional amplitude of low frequency fluctuations (fALFF) and the number of OCS were explored by using a general linear model, considering fALFF as response variable, OCS score as regressor and age, gender and site as nuisance variables. RESULTS: The number of OCS was positively correlated with the fALFF coefficients at the right sensorimotor cortex (pre-motor, primary motor cortex and post-central gyrus) and negatively correlated with the fALFF coefficients at the insula/superior temporal gyrus of both hemispheres. Our results were specific to OCS and not due to associations with overall psychopathology. CONCLUSIONS: Our results suggest that brain spontaneous activity at rest in the sensorimotor and insular/superior-temporal cortices may be involved in OCS in children. These findings need independent replication and future studies should determine whether brain spontaneous activity changes within these regions might be predictors of risk for obsessive-compulsive disorder latter in life.
BACKGROUND: The present study was designed to explore alterations in brain dynamics at rest that are associated with Obsessive Compulsive Symptoms (OCS) in childhood by measuring low frequency fluctuation of spontaneous brain activity in a large school community sample from a developing country. METHOD: Resting state functional magnetic resonance imaging data were collected in a sample of 655 children and adolescents (6-15 years old) from the brazilian 'High Risk Cohort Study for Psychiatric Disorders (HRC)'. OCS were assessed using items from the Compulsion and Obsessions section of the Development and Well-Being Assessment (DAWBA). The correlation between the fractional amplitude of low frequency fluctuations (fALFF) and the number of OCS were explored by using a general linear model, considering fALFF as response variable, OCS score as regressor and age, gender and site as nuisance variables. RESULTS: The number of OCS was positively correlated with the fALFF coefficients at the right sensorimotor cortex (pre-motor, primary motor cortex and post-central gyrus) and negatively correlated with the fALFF coefficients at the insula/superior temporal gyrus of both hemispheres. Our results were specific to OCS and not due to associations with overall psychopathology. CONCLUSIONS: Our results suggest that brain spontaneous activity at rest in the sensorimotor and insular/superior-temporal cortices may be involved in OCS in children. These findings need independent replication and future studies should determine whether brain spontaneous activity changes within these regions might be predictors of risk for obsessive-compulsive disorder latter in life.
Authors: Elizabeth Shephard; Marcelo C Batistuzzo; Marcelo Q Hoexter; Emily R Stern; Pedro F Zuccolo; Carolina Y Ogawa; Renata M Silva; Andre R Brunoni; Daniel L Costa; Victoria Doretto; Leonardo Saraiva; Carolina Cappi; Roseli G Shavitt; H Blair Simpson; Odile A van den Heuvel; Euripedes C Miguel Journal: Braz J Psychiatry Date: 2022 Mar-Abr
Authors: Geraldo Busatto Filho; Pedro G Rosa; Mauricio H Serpa; Paula Squarzoni; Fabio L Duran Journal: Braz J Psychiatry Date: 2020-06-08 Impact factor: 2.697
Authors: Alessandra Cirillo; Elton Diniz; Ary Gadelha; Elson Asevedo; Luiza K Axelrud; Eurípedes C Miguel; Luis Augusto Rohde; Rodrigo A Bressan; Pedro Pan; Jair de J Mari Journal: Braz J Psychiatry Date: 2020-04-03 Impact factor: 2.697