Gilles Billebeau1, Martin Etienne2, Riadh Cheikh-Khelifa1, Daniele Vauthier-Brouzes2, Estelle Gandjbakhch1, Richard Isnard1, Jacky Nizard2, Michel Komajda1, Marc Dommergues2, Philippe Charron3. 1. Centre de référence pour les maladies cardiaques héréditaires, hôpital de la Pitié-Salpêtrière, ICAN, AP-HP, 47, boulevard de l'Hôpital, 75013 Paris, France; Département de cardiologie, hôpital de la Pitié-Salpêtrière, AP-HP, 75013 Paris, France. 2. Service de gynécologie obstétrique, hôpital de la Pitié-Salpêtrière, AP-HP, 75013 Paris, France. 3. Centre de référence pour les maladies cardiaques héréditaires, hôpital de la Pitié-Salpêtrière, ICAN, AP-HP, 47, boulevard de l'Hôpital, 75013 Paris, France; CESP, Inserm U1018, service de génétique, hôpital Ambroise-Paré, université Versailles-Saint-Quentin, AP-HP, 92100 Boulogne-Billancourt, France. Electronic address: philippe.charron@aphp.fr.
Abstract
BACKGROUND: Pregnancies in women with pre-existing cardiomyopathies are considered at high risk for complications. However, few data are available to characterize their natural history and predict the outcome. AIMS: Our aim was to evaluate the prevalence and predictors of acute cardiac and obstetric events in women with a cardiomyopathy during pregnancy, excluding peripartum cardiomyopathy. METHODS: In this retrospective study in a referral centre for cardiomyopathies, we included 43 consecutive pregnancies in 36 women with dilated, hypertrophic, arrhythmogenic right ventricular or tachycardia-induced cardiomyopathy, or left ventricular non-compaction. RESULTS: We observed a major cardiovascular event during 15 pregnancies (35%), including three cardiac deaths, which occurred in patients who did not follow our usual early multidisciplinary protocol. The Carpreg score was predictive of maternal complication rate (67%, 36% and 31% in women with a Carpreg score of 2, 1 and 0, respectively). However, major cardiac complications occurred in four women with no risk factors. Left ventricular ejection fraction alone, gradient in hypertrophic cardiomyopathy, the Zahara score and the modified World Health Organization score appeared to be less discriminant than Carpreg for maternal outcome. There were two intrauterine fetal deaths, nine premature deliveries (23%), 17 low neonatal birth weights (40%) and 11 cases of hypoglycaemia (26%). CONCLUSIONS: Pregnancy in women with a cardiomyopathy is at high risk for both women and neonates. The highest risks are observed in women who do not benefit from early multidisciplinary team management, and in patients with dilated cardiomyopathy. Our findings suggest that the Carpreg score is the most appropriate predictor of maternal complications, although the stratification might be improved.
BACKGROUND: Pregnancies in women with pre-existing cardiomyopathies are considered at high risk for complications. However, few data are available to characterize their natural history and predict the outcome. AIMS: Our aim was to evaluate the prevalence and predictors of acute cardiac and obstetric events in women with a cardiomyopathy during pregnancy, excluding peripartum cardiomyopathy. METHODS: In this retrospective study in a referral centre for cardiomyopathies, we included 43 consecutive pregnancies in 36 women with dilated, hypertrophic, arrhythmogenic right ventricular or tachycardia-induced cardiomyopathy, or left ventricular non-compaction. RESULTS: We observed a major cardiovascular event during 15 pregnancies (35%), including three cardiac deaths, which occurred in patients who did not follow our usual early multidisciplinary protocol. The Carpreg score was predictive of maternal complication rate (67%, 36% and 31% in women with a Carpreg score of 2, 1 and 0, respectively). However, major cardiac complications occurred in four women with no risk factors. Left ventricular ejection fraction alone, gradient in hypertrophic cardiomyopathy, the Zahara score and the modified World Health Organization score appeared to be less discriminant than Carpreg for maternal outcome. There were two intrauterine fetal deaths, nine premature deliveries (23%), 17 low neonatal birth weights (40%) and 11 cases of hypoglycaemia (26%). CONCLUSIONS: Pregnancy in women with a cardiomyopathy is at high risk for both women and neonates. The highest risks are observed in women who do not benefit from early multidisciplinary team management, and in patients with dilated cardiomyopathy. Our findings suggest that the Carpreg score is the most appropriate predictor of maternal complications, although the stratification might be improved.
Authors: Anna I Castrini; Eystein Skjølsvik; Mette E Estensen; Vibeke M Almaas; Helge Skulstad; Erik Lyseggen; Thor Edvardsen; Øyvind H Lie; Kermshlise C I Picard; Neal K Lakdawala; Kristina H Haugaa Journal: J Am Heart Assoc Date: 2022-04-18 Impact factor: 6.106
Authors: Kamala P Tamirisa; Cicely Dye; Rachel M Bond; Lisa M Hollier; Karolina Marinescu; Marmar Vaseghi; Andrea M Russo; Martha Gulati; Annabelle Santos Volgman Journal: J Cardiovasc Dev Dis Date: 2022-06-24
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