Nils Heim1, Felix Benjamin Warwas2, Christian Timm Wilms3, Rudolf H Reich4, Markus Martini5. 1. Department for Oral & Cranio-Maxillo and Facial Plastic Surgery (Head: Prof. Dr. Dr. Rudolf H. Reich), University of Bonn, Bonn, Germany. Electronic address: nils.heim@ukb.ubi-bonn.de. 2. Department for Oral & Cranio-Maxillo and Facial Plastic Surgery (Head: Prof. Dr. Dr. Rudolf H. Reich), University of Bonn, Bonn, Germany. Electronic address: felix.warwas@ukb.uni-bonn.de. 3. Department for Oral & Cranio-Maxillo and Facial Plastic Surgery (Head: Prof. Dr. Dr. Rudolf H. Reich), University of Bonn, Bonn, Germany. Electronic address: christian.wilms@ukb.uni-bonn.de. 4. Department for Oral & Cranio-Maxillo and Facial Plastic Surgery (Head: Prof. Dr. Dr. Rudolf H. Reich), University of Bonn, Bonn, Germany. Electronic address: rudolf.reich@ukb.uni-bonn.de. 5. Department for Oral & Cranio-Maxillo and Facial Plastic Surgery (Head: Prof. Dr. Dr. Rudolf H. Reich), University of Bonn, Bonn, Germany. Electronic address: markus.martini@ukb.uni-bonn.de.
Abstract
INTRODUCTION: Osteonecrosis of the jaw (ONJ) is a severe complication of antiresorptive medication (AM) in the treatment of bone-affecting cancer-related conditions and osteoporosis. Aim of this study was to reveal whether patients treated with AM and show Medication Related OsteoNecrosis of the Jaw (MRONJ) are vitamin D deficient or not. MATERIALS AND METHODS: A 2 year retrospective study evaluated hospital records of 63 patients who received AM. Patients were divided into two groups. One group (n = 45) consisted of patients who presented a stage 2 ONJ (eb+ = exposed bone). Second group patients (n = 18) (eb- = no exposed bone) presented for extraction of teeth. Serum levels of vitamin D (25-OHD) were analysed. P values ≤ 0.05 in t-test were regarded as statistically significant. RESULTS: Serum levels of 25-OHD were significantly higher in the eb(-) group (29.5 ng/ml), than in the eb(+) group (20.49 ng/ml). Blood levels of calcium were also significantly higher in eb(-) group (2.25 mmol/L; 0.11 SD) than in eb(+) group (2.175 mmol/L; 0.16 SD). CONCLUSION: Prevalence of MRONJ in AM treated patients seems to be increased by low serum 25-OHD. A measurable tendency in the role of 25-OHD for the development of MRONJ was recorded and leads to the recommendation for a sufficient vitamin D substitution in patients treated with AM.
INTRODUCTION:Osteonecrosis of the jaw (ONJ) is a severe complication of antiresorptive medication (AM) in the treatment of bone-affecting cancer-related conditions and osteoporosis. Aim of this study was to reveal whether patients treated with AM and show Medication Related OsteoNecrosis of the Jaw (MRONJ) are vitamin Ddeficient or not. MATERIALS AND METHODS: A 2 year retrospective study evaluated hospital records of 63 patients who received AM. Patients were divided into two groups. One group (n = 45) consisted of patients who presented a stage 2 ONJ (eb+ = exposed bone). Second group patients (n = 18) (eb- = no exposed bone) presented for extraction of teeth. Serum levels of vitamin D (25-OHD) were analysed. P values ≤ 0.05 in t-test were regarded as statistically significant. RESULTS: Serum levels of 25-OHD were significantly higher in the eb(-) group (29.5 ng/ml), than in the eb(+) group (20.49 ng/ml). Blood levels of calcium were also significantly higher in eb(-) group (2.25 mmol/L; 0.11 SD) than in eb(+) group (2.175 mmol/L; 0.16 SD). CONCLUSION: Prevalence of MRONJ in AM treated patients seems to be increased by low serum 25-OHD. A measurable tendency in the role of 25-OHD for the development of MRONJ was recorded and leads to the recommendation for a sufficient vitamin D substitution in patients treated with AM.
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