Literature DB >> 29101747

Cloning, intracellular localization, and expression of the mammalian selenocysteine-containing protein SELENOI (SelI) in tumor cell lines.

E G Varlamova1, M V Goltyaev2, V I Novoselov2, E E Fesenko2.   

Abstract

The intracellular localization of human selenoprotein SelI and the degree of expression of its gene in different human tumor cell lines were determined. It was found that the SelI protein is present in the nucleus, cytoplasm, and endoplasmic reticulum and is absent in the nucleolus. Since the oxidative stress caused by a sharp increase in the content of free radicals in the body is one of the causes of malignant transformation, the study of the role of the trace element selenium and selenocysteine-containing proteins as antioxidants in carcinogenesis is of great scientific interest.

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Year:  2017        PMID： 29101747     DOI： 10.1134/S160767291705012X

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  12 in total

1.  Extensive feature detection of N-terminal protein sorting signals.

Authors:  Hideo Bannai; Yoshinori Tamada; Osamu Maruyama; Kenta Nakai; Satoru Miyano
Journal:  Bioinformatics       Date:  2002-02       Impact factor: 6.937

2.  Improved prediction of signal peptides: SignalP 3.0.

Authors:  Jannick Dyrløv Bendtsen; Henrik Nielsen; Gunnar von Heijne; Søren Brunak
Journal:  J Mol Biol       Date:  2004-07-16       Impact factor: 5.469

3.  Overexpression of Selenoprotein SelK in BGC-823 Cells Inhibits Cell Adhesion and Migration.

Authors:  S B Ben; B Peng; G C Wang; C Li; H F Gu; H Jiang; X L Meng; B J Lee; C L Chen
Journal:  Biochemistry (Mosc)       Date:  2015-10       Impact factor: 2.487

4.  Better prediction of protein cellular localization sites with the k nearest neighbors classifier.

Authors:  P Horton; K Nakai
Journal:  Proc Int Conf Intell Syst Mol Biol       Date:  1997

5.  Expression of human selenoprotein genes selh, selk, selm, sels, selv, and gpx-6 in various tumor cell lines.

Authors:  E G Varlamova; M V Goltyaev; E E Fesenko
Journal:  Dokl Biochem Biophys       Date:  2016-07-15       Impact factor: 0.788

Review 6.  Integration of calcium and Ras signalling.

Authors:  Peter J Cullen; Peter J Lockyer
Journal:  Nat Rev Mol Cell Biol       Date:  2002-05       Impact factor: 94.444

7.  Predicting subcellular localization of proteins based on their N-terminal amino acid sequence.

Authors:  O Emanuelsson; H Nielsen; S Brunak; G von Heijne
Journal:  J Mol Biol       Date:  2000-07-21       Impact factor: 5.469

8.  Essential role of TRPC6 channels in G2/M phase transition and development of human glioma.

Authors:  Xia Ding; Zhuohao He; Kechun Zhou; Ju Cheng; Hailan Yao; Dongliang Lu; Rong Cai; Yening Jin; Bin Dong; Yinghui Xu; Yizheng Wang
Journal:  J Natl Cancer Inst       Date:  2010-06-16       Impact factor: 13.506

9.  The neuroprotective functions of selenoprotein M and its role in cytosolic calcium regulation.

Authors:  Mariclair A Reeves; Frederick P Bellinger; Marla J Berry
Journal:  Antioxid Redox Signal       Date:  2010-04-01       Impact factor: 8.401

10.  Characterization of mammalian selenoproteomes.

Authors:  Gregory V Kryukov; Sergi Castellano; Sergey V Novoselov; Alexey V Lobanov; Omid Zehtab; Roderic Guigó; Vadim N Gladyshev
Journal:  Science       Date:  2003-05-30       Impact factor: 47.728
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  3 in total

Review 1.  Selenoproteins in colon cancer.

Authors:  Kristin M Peters; Bradley A Carlson; Vadim N Gladyshev; Petra A Tsuji
Journal:  Free Radic Biol Med       Date:  2018-05-22       Impact factor: 7.376

2.  Activation of Signal Pathways of Apoptosis under Conditions of Prolonged ER-Stress Caused by Exposure of Mouse Testicular Teratoma Cells to Selenium-Containing Compounds.

Authors:  M V Goltyaev; E G Varlamova; S V Novoselov; E E Fesenko
Journal:  Dokl Biochem Biophys       Date:  2020-04-27       Impact factor: 0.788

3.  The Role of Selenoproteins SELENOM and SELENOT in the Regulation of Apoptosis, ER Stress, and Calcium Homeostasis in the A-172 Human Glioblastoma Cell Line.

Authors:  Elena G Varlamova; Michael V Goltyaev; Egor A Turovsky
Journal:  Biology (Basel)       Date:  2022-05-25
  3 in total

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