| Literature DB >> 29101655 |
Naiomy Deliz Rios-Arce1,2, Fraser L Collins2, Jonathan D Schepper2, Michael D Steury2, Sandi Raehtz2, Heather Mallin2, Danny T Schoenherr2, Narayanan Parameswaran3,4, Laura R McCabe5.
Abstract
The intestinal epithelial barrier plays an essential role in maintaining host homeostasis. The barrier regulates nutrient absorption as well as prevents the invasion of pathogenic bacteria in the host. It is composed of epithelial cells, tight junctions, and a mucus layer. Several factors, such as cytokines, diet, and diseases, can affect this barrier. These factors have been shown to increase intestinal permeability, inflammation, and translocation of pathogenic bacteria. In addition, dysregulation of the epithelial barrier can result in inflammatory diseases such as inflammatory bowel disease. Our lab and others have also shown that barrier disruption can have systemic effects including bone loss. In this chapter, we will discuss the current literature to understand the link between intestinal barrier and bone. We will discuss how inflammation, aging, dysbiosis, and metabolic diseases can affect intestinal barrier-bone link. In addition, we will highlight the current suggested mechanism between intestinal barrier and bone.Entities:
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Year: 2017 PMID： 29101655 PMCID： PMC5742533 DOI： 10.1007/978-3-319-66653-2_8
Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622