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Literature DB >> 29101250

Phosphoproteomics links glycogen synthase kinase-3 to RNA splicing.

Abstract

Protein kinases play essential biological roles by phosphorylating a diverse range of signaling molecules, but deciphering their direct physiological targets remains a challenge. A new study by Shinde et al. uses phosphoproteomics to identify glycogen synthase kinase-3 (GSK-3) substrates in mouse embryonic stem cells (mESCs), providing a broad profile of GSK-3 activity and defining a new role for this central kinase in regulating RNA splicing.

Entities: Gene Species

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Year: 2017 PMID： 29101250 PMCID： PMC5672047 DOI： 10.1074/jbc.H117.813527

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

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References

10 in total

1. Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition.

Authors: R Dajani; E Fraser; S M Roe; N Young; V Good; T C Dale; L H Pearl
Journal: Cell Date: 2001-06-15 Impact factor: 41.582

2. Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines.

Authors: Bradley W Doble; Satish Patel; Geoffrey A Wood; Lisa K Kockeritz; James R Woodgett
Journal: Dev Cell Date: 2007-06 Impact factor: 12.270

Review 3. Mechanisms of specificity in protein phosphorylation.

Authors: Jeffrey A Ubersax; James E Ferrell
Journal: Nat Rev Mol Cell Biol Date: 2007-07 Impact factor: 94.444

4. Phosphoproteomics reveals that glycogen synthase kinase-3 phosphorylates multiple splicing factors and is associated with alternative splicing.

Authors: Mansi Y Shinde; Simone Sidoli; Katarzyna Kulej; Michael J Mallory; Caleb M Radens; Amanda L Reicherter; Rebecca L Myers; Yoseph Barash; Kristen W Lynch; Benjamin A Garcia; Peter S Klein
Journal: J Biol Chem Date: 2017-09-15 Impact factor: 5.157

5. The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells.

Authors: Qiong Wang; Yilong Zou; Sonja Nowotschin; Sang Yong Kim; Qing V Li; Chew-Li Soh; Jie Su; Chao Zhang; Weiping Shu; Qiaoran Xi; Danwei Huangfu; Anna-Katerina Hadjantonakis; Joan Massagué
Journal: Cell Stem Cell Date: 2016-11-23 Impact factor: 24.633

10. Widespread JNK-dependent alternative splicing induces a positive feedback loop through CELF2-mediated regulation of MKK7 during T-cell activation.

Authors: Nicole M Martinez; Laura Agosto; Jinsong Qiu; Michael J Mallory; Matthew R Gazzara; Yoseph Barash; Xiang-Dong Fu; Kristen W Lynch
Journal: Genes Dev Date: 2015-10-01 Impact factor: 11.361

10 in total

Phosphoproteomics links glycogen synthase kinase-3 to RNA splicing.

1. Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition.

2. Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines.

Review 3. Mechanisms of specificity in protein phosphorylation.

4. Phosphoproteomics reveals that glycogen synthase kinase-3 phosphorylates multiple splicing factors and is associated with alternative splicing.

5. The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells.

6. Phosphorylation-dependent regulation of PSF by GSK3 controls CD45 alternative splicing.

7. What Are the bona fide GSK3 Substrates?

Review 8. GSK3: a multifaceted kinase in Wnt signaling.

9. Novel reporter alleles of GSK-3α and GSK-3β.

10. Widespread JNK-dependent alternative splicing induces a positive feedback loop through CELF2-mediated regulation of MKK7 during T-cell activation.