Literature DB >> 29101014

Integrin-linked kinase: A new actor in the ageing process?

Gemma Olmos1, Susana López-Ongil2, Maria Piedad Ruiz Torres3.   

Abstract

Integrin-linked kinase (ILK) is a protein located in focal adhesion complexes that is linked to the cytoplasmic domain of integrin receptors. Together with PINCH and parvin, ILK forms the IPP complex, which is associated with conserved intracellular signalling pathways and integrin regulation of the actin cytoskeleton. ILK plays an essential role in a wide variety of cellular functions, including cell migration, differentiation, survival, and division. The present review summarizes recent evidence, suggesting a new role for ILK in organismal ageing and cellular senescence, indicating that ILK is a key regulator of longevity and premature cellular senescence induced by extracellular stressors.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Extracellular matrix; Longevity; Senescence

Mesh：

Substances：

Year:  2017        PMID： 29101014     DOI： 10.1016/j.exger.2017.10.026

Source DB:  PubMed          Journal:  Exp Gerontol        ISSN： 0531-5565            Impact factor:   4.032


  8 in total

1.  [Role of TGF-β1/ILK/FSP1 signaling pathway in cyclosporin A-induced epithelialmesenchymal transition in cultured renal tubular epithelial cells].

Authors:  Zhixun Bai; Jing Lu; Yibin Yang
Journal:  Nan Fang Yi Ke Da Xue Xue Bao       Date:  2019-07-30

2.  The kinase activity of integrin-linked kinase regulates cellular senescence in gastric cancer.

Authors:  Chengbo Ji; Mili Zhang; Junjie Hu; Can Cao; Qisheng Gu; Youdong Liu; Xu Li; Duogang Xu; Le Ying; Yuqin Yang; Hugh Gao; Jikun Li; Liang Yu
Journal:  Cell Death Dis       Date:  2022-07-01       Impact factor: 9.685

3.  Effect of transplantation of cardiac stem cells overexpressing integrin-linked kinase on cardiac function of rats with acute myocardial infarction.

Authors:  Fengli Zhang; Fengyan Guo
Journal:  Exp Ther Med       Date:  2018-05-18       Impact factor: 2.447

Review 4.  Integrin-linked kinase (ILK): the known vs. the unknown and perspectives.

Authors:  Agata Górska; Antonina Joanna Mazur
Journal:  Cell Mol Life Sci       Date:  2022-01-28       Impact factor: 9.261

5.  ATP allosterically stabilizes integrin-linked kinase for efficient force generation.

Authors:  Isabel M Martin; Michele M Nava; Sara A Wickström; Frauke Gräter
Journal:  Proc Natl Acad Sci U S A       Date:  2022-03-08       Impact factor: 11.205

6.  Therapeutic effect of integrin-linked kinase gene-modified bone marrow-derived mesenchymal stem cells for streptozotocin-induced diabetic cystopathy in a rat model.

Authors:  Yi Huang; Jie Gao; Yiduo Zhou; Shuo Wu; Yunpeng Shao; Haoliang Xue; Baixin Shen; Liucheng Ding; Zhongqing Wei
Journal:  Stem Cell Res Ther       Date:  2020-07-10       Impact factor: 6.832

7.  A transcriptomic analysis of serial-cultured, tonsil-derived mesenchymal stem cells reveals decreased integrin α3 protein as a potential biomarker of senescent cells.

Authors:  Da Hyeon Choi; Se-Young Oh; Ju Kwang Choi; Kyeong Eun Lee; Ju Yeon Lee; Yoon Jeong Park; Inho Jo; Yoon Shin Park
Journal:  Stem Cell Res Ther       Date:  2020-08-17       Impact factor: 6.832

Review 8.  Targeting Epigenetic Mechanisms in Vascular Aging.

Authors:  Zhongxiao Lin; Qian Ding; Xinzhi Li; Yuliang Feng; Hao He; Chuoji Huang; YiZhun Zhu
Journal:  Front Cardiovasc Med       Date:  2022-01-04
  8 in total

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