| Literature DB >> 29100069 |
Michael A Reid1, Jihye Paik2, Jason W Locasale3.
Abstract
Nearly 3% of the human population carries bi-allelic loss-of-function variants in the gene encoding CLYBL. While largely healthy, these individuals exhibit reduced circulating vitamin B12 levels. In this issue of Cell, Shen and colleagues uncover the metabolic role of CLYBL, linking its function to B12 metabolism and the immunomodulatory metabolite, itaconate.Entities:
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Year: 2017 PMID： 29100069 DOI： 10.1016/j.cell.2017.10.030
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582