| Literature DB >> 29100008 |
Albert Ruzo1, Ali H Brivanlou2.
Abstract
Our understanding of early human development is typically based on inference from animal models, which may not fully recapitulate human embryonic features. As proof of concept, Fogarty et al. (2017) used CRISPR/Cas9 to genetically ablate the OCT4 gene in human preimplantation embryos and found key differences from its function in model systems.Entities:
Mesh：
Year: 2017 PMID： 29100008 DOI： 10.1016/j.stem.2017.10.008
Source DB: PubMed Journal: Cell Stem Cell ISSN： 1875-9777 Impact factor: 24.633