Literature DB >> 29098537

Duplex Tear Film Evaporation Analysis.

M R Stapf1, R J Braun2, P E King-Smith3.   

Abstract

Tear film thinning, hyperosmolarity, and breakup can cause irritation and damage to the human eye, and these form an area of active investigation for dry eye syndrome research. Recent research demonstrates that deficiencies in the lipid layer may cause locally increased evaporation, inducing conditions for breakup. In this paper, we explore the conditions for tear film breakup by considering a model for tear film dynamics with two mobile fluid layers, the aqueous and lipid layers. In addition, we include the effects of osmosis, evaporation as modified by the lipid, and the polar portion of the lipid layer. We solve the system numerically for reasonable parameter values and initial conditions and analyze how shifts in these cause changes to the system's dynamics.

Entities:  

Keywords:  Evaporation; Lipid layer; Tear film; Tear osmolarity

Mesh:

Substances:

Year:  2017        PMID: 29098537     DOI: 10.1007/s11538-017-0351-9

Source DB:  PubMed          Journal:  Bull Math Biol        ISSN: 0092-8240            Impact factor:   1.758


  2 in total

1.  Mathematical modelling of glob-driven tear film breakup.

Authors:  L Zhong; C F Ketelaar; R J Braun; C G Begley; P E King-Smith
Journal:  Math Med Biol       Date:  2019-03-14       Impact factor: 1.854

2.  Dynamics of Fluorescent Imaging for Rapid Tear Thinning.

Authors:  L Zhong; R J Braun; C G Begley; P E King-Smith
Journal:  Bull Math Biol       Date:  2018-10-15       Impact factor: 1.758

  2 in total

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