Literature DB >> 29097110

Role of tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and associated proteins in coronary artery disease and cardiac events.

Melody Chemaly1, Victoria McGilligan2, Mark Gibson3, Matthias Clauss4, Steven Watterson2, H Denis Alexander2, Anthony John Bjourson2, Aaron Peace5.   

Abstract

Tumour necrosis factor alpha converting enzyme (TACE/ADAM17) is a member of the A disintegrin and metalloproteinase (ADAM) family of ectodomain shedding proteinases. It regulates many inflammatory processes by cleaving several transmembrane proteins, including tumour necrosis factor alpha (TNFα) and its receptors tumour necrosis factor alpha receptor 1 and tumour necrosis factor alpha receptor 2. There is evidence that TACE is involved in several inflammatory diseases, such as ischaemia, heart failure, arthritis, atherosclerosis, diabetes and cancer as well as neurological and immune diseases. This review summarizes the latest discoveries regarding the mechanism of action and regulation of TACE. It also focuses on the role of TACE in atherosclerosis and coronary artery disease (CAD), highlighting clinical studies that have investigated its expression and protein activity. The multitude of substrates cleaved by TACE make this enzyme an attractive target for therapy and a candidate for biomarker research and development in CAD. Crown
Copyright © 2017. Published by Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Atherosclerosis; Athérosclérose; Biomarker; Biomarqueur; Protéines transmembrannaires; TACE; TNFα; Transmembrane proteins

Mesh：

Substances：

Year:  2017        PMID： 29097110     DOI： 10.1016/j.acvd.2017.08.002

Source DB:  PubMed          Journal:  Arch Cardiovasc Dis        ISSN： 1875-2128            Impact factor:   2.340


  8 in total

1.  ADAM and ADAMTS disintegrin and metalloproteinases as major factors and molecular targets in vascular malfunction and disease.

Authors:  HaiFeng Yang; Raouf A Khalil
Journal:  Adv Pharmacol       Date:  2022-01-24

2.  Deficiency of inactive rhomboid protein 2 (iRhom2) attenuates diet-induced hyperlipidaemia and early atherogenesis.

Authors:  Carmen Hannemann; Johannes H Schecker; Alica Brettschneider; Jana Grune; Nicole Rösener; Andrea Weller; Verena Stangl; Edward A Fisher; Karl Stangl; Antje Ludwig; Bernd Hewing
Journal:  Cardiovasc Res       Date:  2022-01-07       Impact factor: 10.787

3.  Molecular chronicles of cytokine burst in patients with coronavirus disease 2019 (COVID-19) with cardiovascular diseases.

Authors:  Finosh G Thankam; Devendra K Agrawal
Journal:  J Thorac Cardiovasc Surg       Date:  2020-06-06       Impact factor: 5.209

4.  The hypoxia-sensor carbonic anhydrase IX affects macrophage metabolism, but is not a suitable biomarker for human cardiovascular disease.

Authors:  J A F Demandt; L J Dubois; K van Kuijk; M Zaťovičová; H Jin; S Parkkila; S W van der Laan; L Jelenska; B M E Mees; C P M Reutelingsperger; K B J M Cleutjens; C J H van der Kallen; C G Schalkwijk; M M J van Greevenbroek; E A L Biessen; G Pasterkamp; S Pastoreková; C D A Stehouwer; J C Sluimer
Journal:  Sci Rep       Date:  2021-01-11       Impact factor: 4.379

5.  Syzygium Polyanthum Reduced TNF-α and ADAM17 Protein Expression in Myocardial Infarction Rat Model.

Authors:  Refli Hasan; Gontar Alamsyah Siregar; Dharma Lindarto
Journal:  Med Arch       Date:  2020-12

Review 6.  The Synergy of ADAM17-Induced Myocardial Inflammation and Metabolic Lipids Dysregulation During Acute Stress: New Pathophysiologic Insights Into Takotsubo Cardiomyopathy.

Authors:  Joseph Adu-Amankwaah; Gabriel Komla Adzika; Adebayo Oluwafemi Adekunle; Marie Louise Ndzie Noah; Richard Mprah; Aisha Bushi; Nazma Akhter; Yaxin Xu; Fei Huang; Benard Chatambarara; Hong Sun
Journal:  Front Cardiovasc Med       Date:  2021-06-04

Review 7.  ADAM17, A Key Player of Cardiac Inflammation and Fibrosis in Heart Failure Development During Chronic Catecholamine Stress.

Authors:  Joseph Adu-Amankwaah; Gabriel Komla Adzika; Adebayo Oluwafemi Adekunle; Marie Louise Ndzie Noah; Richard Mprah; Aisha Bushi; Nazma Akhter; Fei Huang; Yaxin Xu; Seyram Yao Adzraku; Iqra Nadeem; Hong Sun
Journal:  Front Cell Dev Biol       Date:  2021-12-13

8.  Vitamin D3 Prevents the Deleterious Effects of Testicular Torsion on Testis by Targeting miRNA-145 and ADAM17: In Silico and In Vivo Study.

Authors:  Doaa I Mohamed; Doaa A Abou-Bakr; Samar F Ezzat; Hanaa F Abd El-Kareem; Hebatallah H Abo Nahas; Hosam A Saad; Amir E Mehana; Essa M Saied
Journal:  Pharmaceuticals (Basel)       Date:  2021-11-25
  8 in total

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