Literature DB >> 29097023

Vav1: Friend and Foe of Cancer.

Fukun Guo1, Yi Zheng2.   

Abstract

A recent study shows that the protumorigenic guanine nucleotide exchange factor (GEF) Vav1 functions as a tumor suppressor in T cell acute lymphoblastic leukemia (T-ALL) through its ability to complex with the Cbl-b ubiquitin ligase and the intracellular domain of Notch1 (ICN1) and to promote ICN1 degradation. Vav1can act as a double-edged sword in tumorigenesis.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Notch 1; Rho GEF; T-ALL; Vav1; oncogene; tumor suppressor

Year:  2017        PMID： 29097023      PMCID： PMC5696075          DOI： 10.1016/j.tcb.2017.10.004

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN： 0962-8924            Impact factor:   20.808


  10 in total

Review 1.  Rho GTPases in cell biology.

Authors:  Sandrine Etienne-Manneville; Alan Hall
Journal:  Nature       Date:  2002-12-12       Impact factor: 49.962

Review 2.  RHO-GTPases and cancer.

Authors:  Erik Sahai; Christopher J Marshall
Journal:  Nat Rev Cancer       Date:  2002-02       Impact factor: 60.716

3.  Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia.

Authors:  Daniel J Hodson; Michelle L Janas; Alison Galloway; Sarah E Bell; Simon Andrews; Cheuk M Li; Richard Pannell; Christian W Siebel; H Robson MacDonald; Kim De Keersmaecker; Adolfo A Ferrando; Gerald Grutz; Martin Turner
Journal:  Nat Immunol       Date:  2010-07-11       Impact factor: 25.606

4.  Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis.

Authors:  Martin E Fernandez-Zapico; Natalia C Gonzalez-Paz; Ellen Weiss; Doris N Savoy; Julian R Molina; Rafael Fonseca; Thomas C Smyrk; Suresh T Chari; Raul Urrutia; Daniel D Billadeau
Journal:  Cancer Cell       Date:  2005-01       Impact factor: 31.743

Review 5.  GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors.

Authors:  Kent L Rossman; Channing J Der; John Sondek
Journal:  Nat Rev Mol Cell Biol       Date:  2005-02       Impact factor: 94.444

6.  Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation.

Authors:  X R Bustelo; P Crespo; M López-Barahona; J S Gutkind; M Barbacid
Journal:  Oncogene       Date:  1997-11-20       Impact factor: 9.867

7.  Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lymphomas.

Authors:  Francesco Abate; Ana C da Silva-Almeida; Sakellarios Zairis; Javier Robles-Valero; Lucile Couronne; Hossein Khiabanian; S Aidan Quinn; Mi-Yeon Kim; Maria Antonella Laginestra; Christine Kim; Danilo Fiore; Govind Bhagat; Miguel Angel Piris; Elias Campo; Izidore S Lossos; Olivier A Bernard; Giorgio Inghirami; Stefano Pileri; Xosé R Bustelo; Raul Rabadan; Adolfo A Ferrando; Teresa Palomero
Journal:  Proc Natl Acad Sci U S A       Date:  2017-01-06       Impact factor: 11.205

Review 8.  Rho GTPases: Anti- or pro-neoplastic targets?

Authors:  I Zandvakili; Y Lin; J C Morris; Y Zheng
Journal:  Oncogene       Date:  2016-12-19       Impact factor: 9.867

Review 9.  Vav family exchange factors: an integrated regulatory and functional view.

Authors:  Xosé R Bustelo
Journal:  Small GTPases       Date:  2014

10.  A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia.

Authors:  Javier Robles-Valero; L Francisco Lorenzo-Martín; Mauricio Menacho-Márquez; Isabel Fernández-Pisonero; Antonio Abad; Mireia Camós; María L Toribio; Lluis Espinosa; Anna Bigas; Xosé R Bustelo
Journal:  Cancer Cell       Date:  2017-11-13       Impact factor: 31.743
  10 in total
  1 in total

1.  The Heterogeneity of Infiltrating Macrophages in Metastatic Osteosarcoma and Its Correlation with Immunotherapy.

Authors:  Zhanchao Wang; Huiqiao Wu; Yu Chen; Huajiang Chen; Wen Yuan; Xinwei Wang
Journal:  J Oncol       Date:  2021-07-21       Impact factor: 4.375
  1 in total

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