Literature DB >> 2909657

Role of the thymus in natural tolerance to an autologous protein antigen.

M Boguniewicz1, G H Sunshine, Y Borel.   

Abstract

C5-deficient mice grafted with thymus from C5-sufficient donors and immunized with C5 failed to make humoral antibody to C5, suggesting that the transfer of thymus had induced tolerance. Irradiated C5-deficient hosts repopulated with lymphoid cells from thymectomized C5-deficient mice grafted with C5-sufficient thymus also failed to respond to immunization with C5, thus showing that the state of tolerance can be adoptively transferred. These results demonstrate that natural tolerance to self-protein antigen is "learned" in the thymus.

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Year:  1989        PMID： 2909657      PMCID： PMC2189186          DOI： 10.1084/jem.169.1.285

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  18 in total

Review 1.  The somatic generation of immune recognition.

Authors:  N K Jerne
Journal:  Eur J Immunol       Date:  1971-01       Impact factor: 5.532

2.  Spontaneous thyroiditis in the obese strain of chickens. IV. The effect of thymectomy and thymo-bursectomy on the development of the disease.

Authors:  G Wick; J H Kite; E Witebsky
Journal:  J Immunol       Date:  1970-01       Impact factor: 5.422

3.  Functional clonal deletion of cytotoxic T-lymphocyte precursors in chimeric thymus produced in vitro from embryonic Anlagen.

Authors:  M F Good; K W Pyke; G J Nossal
Journal:  Proc Natl Acad Sci U S A       Date:  1983-05       Impact factor: 11.205

4.  Genetic defect in secretion of complement C5 in mice.

Authors:  Y M Ooi; H R Colten
Journal:  Nature       Date:  1979-11-08       Impact factor: 49.962

5.  Successful transplantation across major histocompatibility barrier of deoxyguanosine-treated embryonic thymus expressing class II antigens.

Authors:  A R Ready; E J Jenkinson; R Kingston; J J Owen
Journal:  Nature       Date:  1984 Jul 19-25       Impact factor: 49.962

6.  Role of prethymic cells in acquisition of self-tolerance.

Authors:  H O Besedovsky; A del Rey; E Sorkin
Journal:  J Exp Med       Date:  1979-12-01       Impact factor: 14.307

7.  Distinct recognition phenotypes exist for T cell clones specific for small peptide regions of proteins. Implications for the mechanisms underlying major histocompatibility complex-restricted antigen recognition and clonal deletion models of immune response gene defects.

Authors:  N Shastri; A Oki; A Miller; E E Sercarz
Journal:  J Exp Med       Date:  1985-07-01       Impact factor: 14.307

8.  Human monocyte spreading induced by factor Bb of the alternative pathway of complement activation. A possible role for C5 in monocyte spreading.

Authors:  J S Sundsmo; O Götze
Journal:  J Exp Med       Date:  1981-09-01       Impact factor: 14.307

9.  A natural model of immunologic tolerance. Tolerance to murine C5 is mediated by T cells, and antigen is required to maintain unresponsiveness.

Authors:  D E Harris; L Cairns; F S Rosen; Y Borel
Journal:  J Exp Med       Date:  1982-08-01       Impact factor: 14.307

10.  Postthymectomy wasting associated with autoimmune phenomena. I. Antiglobulin-positive anemia in A and C57BL-6 Ks mice.

Authors:  E J Yunis; R Hong; M A Grewe; C Martinez; E Cornelius; R A Good
Journal:  J Exp Med       Date:  1967-05-01       Impact factor: 14.307
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  1 in total

1.  Induction of active immunological hypo/non-responsiveness to C5 in adult C5-deficient DBA/2 mice.

Authors:  C W van den Berg; F M Hofhuis; P M Rademaker; H van Dijk
Journal:  Immunology       Date:  1991-11       Impact factor: 7.397
  1 in total

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