Literature DB >> 29096071

Molecular Neuroscience in the 21st Century: A Personal Perspective.

Thomas C Südhof1.   

Abstract

Neuroscience is inherently interdisciplinary in its quest to explain the brain. Like all biological structures, the brain operates at multiple levels, from nano-scale molecules to meter-scale systems. Here, I argue that understanding the nano-scale organization of the brain is not only helpful for insight into its function, but is a requisite for such insight. I propose that one impediment to a better understanding of the brain is that most of its molecular processes are incompletely understood, and suggest a number of key questions that require our attention so that progress can be achieved in neuroscience beyond a description of the activity of neural circuits.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  cytoskeleton; memory; microglia; microvasculature; neural circuit; neuropeptides; spine; synapse formation; synaptic plasticity; synaptic transmission

Mesh:

Year:  2017        PMID: 29096071      PMCID: PMC5689449          DOI: 10.1016/j.neuron.2017.10.005

Source DB:  PubMed          Journal:  Neuron        ISSN: 0896-6273            Impact factor:   17.173


  32 in total

Review 1.  Neuronal specification in the spinal cord: inductive signals and transcriptional codes.

Authors:  T M Jessell
Journal:  Nat Rev Genet       Date:  2000-10       Impact factor: 53.242

Review 2.  Cbln1 and the δ2 glutamate receptor--an orphan ligand and an orphan receptor find their partners.

Authors:  Keiko Matsuda; Michisuke Yuzaki
Journal:  Cerebellum       Date:  2012-03       Impact factor: 3.847

Review 3.  Expression mechanisms underlying long-term potentiation: a postsynaptic view.

Authors:  Roger A Nicoll
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2003-04-29       Impact factor: 6.237

4.  Synaptic pruning by microglia is necessary for normal brain development.

Authors:  Rosa C Paolicelli; Giulia Bolasco; Francesca Pagani; Laura Maggi; Maria Scianni; Patrizia Panzanelli; Maurizio Giustetto; Tiago Alves Ferreira; Eva Guiducci; Laura Dumas; Davide Ragozzino; Cornelius T Gross
Journal:  Science       Date:  2011-07-21       Impact factor: 47.728

5.  TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis.

Authors:  Gernot Kleinberger; Yoshinori Yamanishi; Marc Suárez-Calvet; Eva Czirr; Ebba Lohmann; Elise Cuyvers; Hanne Struyfs; Nadine Pettkus; Andrea Wenninger-Weinzierl; Fargol Mazaheri; Sabina Tahirovic; Alberto Lleó; Daniel Alcolea; Juan Fortea; Michael Willem; Sven Lammich; José L Molinuevo; Raquel Sánchez-Valle; Anna Antonell; Alfredo Ramirez; Michael T Heneka; Kristel Sleegers; Julie van der Zee; Jean-Jacques Martin; Sebastiaan Engelborghs; Asli Demirtas-Tatlidede; Henrik Zetterberg; Christine Van Broeckhoven; Hakan Gurvit; Tony Wyss-Coray; John Hardy; Marco Colonna; Christian Haass
Journal:  Sci Transl Med       Date:  2014-07-02       Impact factor: 17.956

6.  Activation of postsynaptically silent synapses during pairing-induced LTP in CA1 region of hippocampal slice.

Authors:  D Liao; N A Hessler; R Malinow
Journal:  Nature       Date:  1995-06-01       Impact factor: 49.962

7.  Cloning and sequence analysis of cDNA for bovine adrenal preproenkephalin.

Authors:  M Noda; Y Furutani; H Takahashi; M Toyosato; T Hirose; S Inayama; S Nakanishi; S Numa
Journal:  Nature       Date:  1982-01-21       Impact factor: 49.962

8.  An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation.

Authors:  R C Malenka; J A Kauer; D J Perkel; M D Mauk; P T Kelly; R A Nicoll; M N Waxham
Journal:  Nature       Date:  1989-08-17       Impact factor: 49.962

9.  Synaptic signaling by all-trans retinoic acid in homeostatic synaptic plasticity.

Authors:  Jason Aoto; Christine I Nam; Michael M Poon; Pamela Ting; Lu Chen
Journal:  Neuron       Date:  2008-10-23       Impact factor: 17.173

10.  Positional cloning of the mouse obese gene and its human homologue.

Authors:  Y Zhang; R Proenca; M Maffei; M Barone; L Leopold; J M Friedman
Journal:  Nature       Date:  1994-12-01       Impact factor: 49.962

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  20 in total

1.  Imaging and Manipulating Pituitary Function in the Awake Mouse.

Authors:  Ombeline Hoa; Chrystel Lafont; Pierre Fontanaud; Anne Guillou; Yasmine Kemkem; Rhonda D Kineman; Raul M Luque; Tatiana Fiordelisio Coll; Paul Le Tissier; Patrice Mollard
Journal:  Endocrinology       Date:  2019-10-01       Impact factor: 4.736

2.  Performing Single-Cell Clonal Analysis in the Mouse Brain Using Mosaic Analysis with Double Markers (MADM).

Authors:  Wei-Hsiang Huang
Journal:  Methods Mol Biol       Date:  2022

Review 3.  Activity-Regulated Transcription: Bridging the Gap between Neural Activity and Behavior.

Authors:  Ee-Lynn Yap; Michael E Greenberg
Journal:  Neuron       Date:  2018-10-24       Impact factor: 17.173

Review 4.  Synaptic metabolism: a new approach to inborn errors of neurotransmission.

Authors:  Alba Tristán-Noguero; Àngels García-Cazorla
Journal:  J Inherit Metab Dis       Date:  2018-07-16       Impact factor: 4.982

Review 5.  Mitochondrial support and local translation of mitochondrial proteins in synaptic plasticity and function.

Authors:  YongTian Liang
Journal:  Histol Histopathol       Date:  2021-05-25       Impact factor: 2.303

6.  The Comparative Neurology of Neocortical Gyration and the Quest for Functional Specialization.

Authors:  Lazaros C Triarhou
Journal:  Front Syst Neurosci       Date:  2017-12-18

7.  Special Issue on Synapse Assembly, Neural Circuit Development, and Brain Disorders.

Authors:  Jaewon Ko; Eunjoon Kim
Journal:  Exp Mol Med       Date:  2018-04-09       Impact factor: 8.718

Review 8.  Anandamide Revisited: How Cholesterol and Ceramides Control Receptor-Dependent and Receptor-Independent Signal Transmission Pathways of a Lipid Neurotransmitter.

Authors:  Coralie Di Scala; Jacques Fantini; Nouara Yahi; Francisco J Barrantes; Henri Chahinian
Journal:  Biomolecules       Date:  2018-05-22

Review 9.  Molecular Mechanisms of Synaptic Specificity: Spotlight on Hippocampal and Cerebellar Synapse Organizers.

Authors:  Dongseok Park; Sungwon Bae; Taek Han Yoon; Jaewon Ko
Journal:  Mol Cells       Date:  2018-04-18       Impact factor: 5.034

10.  Human white matter and knowledge representation.

Authors:  Franco Pestilli
Journal:  PLoS Biol       Date:  2018-04-26       Impact factor: 8.029

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