Suelen Castro Lavareda Corrêa1, Juliana Elias de Sousa1, Paulo José Pasquali1, Luís Guilherme Scavone de Macedo2, Antonio Carlos Aloise2, Marcelo Lucchesi Teixeira3, André Antonio Pelegrine4. 1. Graduate Student, Department of Implant Dentistry, São Leopoldo Mandic Institute and Research Center, Campinas, Brazil. 2. Assistant Professor, Department of Implant Dentistry, São Leopoldo Mandic Institute and Research Center, Campinas, Brazil. 3. Professor and Head, Department of Prosthodontics, São Leopoldo Mandic Institute and Research Center, Campinas, Brazil. 4. Professor and Head, Department of Implant Dentistry, São Leopoldo Mandic Institute and Research Center, Campinas, Brazil.
Abstract
OBJECTIVES: To evaluate bone allograft associated to bone marrowaspirate concentrate (BMAC), in maxillary reconstructions. MATERIALS AND METHODS:Ten patients with alveolar bone deficiency in the anterior maxilla were randomly divided into control group (CG) and test group (TG). A bone block allograft was placed in both groups, but the graft was impregnated with BMAC only in TG. Computed tomography was performed 7 days (T1) and 6 months (T2) after the grafting procedure, and volume and bone density measurements were carried out. Histomorphometric analysis was performed at T2. RESULTS:Bone volume loss from T1 to T2 was significant only in TG. The bone density in the buccal region of the graft was significantly higher in TG than in CG. There was no significant difference between the groups, in respect to mineralized tissue (MT) and nonmineralized tissue (NMT), in that MT values were 37.77% ± 15.19% and 43.85% ± 10.94%, and NMT values were 62.15% ± 14.90% and 56.30% ± 10.72%, respectively, for CG and TG. The intragroup difference for the MT/NMT ratio was statistically significant in CG but not significant in TG. CONCLUSIONS: The use of BMAC resulted in an improved pattern of bone formation, with higher bone density in the peripheral regions of the graft.
RCT Entities:
OBJECTIVES: To evaluate bone allograft associated to bone marrow aspirate concentrate (BMAC), in maxillary reconstructions. MATERIALS AND METHODS: Ten patients with alveolar bone deficiency in the anterior maxilla were randomly divided into control group (CG) and test group (TG). A bone block allograft was placed in both groups, but the graft was impregnated with BMAC only in TG. Computed tomography was performed 7 days (T1) and 6 months (T2) after the grafting procedure, and volume and bone density measurements were carried out. Histomorphometric analysis was performed at T2. RESULTS: Bone volume loss from T1 to T2 was significant only in TG. The bone density in the buccal region of the graft was significantly higher in TG than in CG. There was no significant difference between the groups, in respect to mineralized tissue (MT) and nonmineralized tissue (NMT), in that MT values were 37.77% ± 15.19% and 43.85% ± 10.94%, and NMT values were 62.15% ± 14.90% and 56.30% ± 10.72%, respectively, for CG and TG. The intragroup difference for the MT/NMT ratio was statistically significant in CG but not significant in TG. CONCLUSIONS: The use of BMAC resulted in an improved pattern of bone formation, with higher bone density in the peripheral regions of the graft.
Authors: Federico Moreno Sancho; Yago Leira; Marco Orlandi; Jacopo Buti; William V Giannobile; Francesco D'Aiuto Journal: Stem Cells Transl Med Date: 2019-11-06 Impact factor: 6.940