Literature DB >> 29095628

Intermolecular Amidation of Quinoline N-Oxides with Arylsulfonamides under Metal-Free Conditions.

Xiaoqiang Yu1, Sana Yang1, Yue Zhang1, Mingju Guo1, Yoshinori Yamamoto1,2, Ming Bao1.   

Abstract

An efficient method for the synthesis of N-(quinolin-2-yl)sulfonamides is described. The intermolecular amidation of quinoline N-oxides with sulfonamides proceeded smoothly in the presence of PhI(OAc)2 and PPh3 to afford N-(quinolin-2-yl)sulfonamides in satisfactory to excellent yields.

Entities:  

Year:  2017        PMID: 29095628     DOI: 10.1021/acs.orglett.7b02922

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  1 in total

1.  Isoquinoline Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-like 2 (KEAP1-NRF2) Inhibitors with High Metabolic Stability.

Authors:  Phillip R Lazzara; Brian P David; Aparna Ankireddy; Benjamin G Richardson; Katherine Dye; Kiira M Ratia; Sekhar P Reddy; Terry W Moore
Journal:  J Med Chem       Date:  2019-11-14       Impact factor: 7.446

  1 in total

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