Literature DB >> 29095627

Total Synthesis of (-)-Geissoschizol through Ir-Catalyzed Allylic Amidation as the Key Step.

Yu Zheng1,2, Kun Wei1, Yu-Rong Yang1.   

Abstract

The iridium-catalyzed, Zn(OTf)2 promoted asymmetric allylic amidation of a secondary alcohol derived from tryptamine has been utilized to forge a tetrahydro-β-carboline. Based on this key step, a novel, facile, and enantioselective total synthesis of (-)-geissoschizol was achieved in 10 steps.

Entities:  

Year:  2017        PMID： 29095627     DOI： 10.1021/acs.orglett.7b03133

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  2 in total

Review 1.  Recent Advances in the Synthesis of β-Carboline Alkaloids.

Authors:  Tímea Szabó; Balázs Volk; Mátyás Milen
Journal:  Molecules       Date:  2021-01-27       Impact factor: 4.411

2.  Palladium catalyzed reductive Heck coupling and its application in total synthesis of (-)-17-nor-excelsinidine.

Authors:  Lisi Yuan; Linrong Chen; Xiaoxiao Yan; Kun Gao; Xiaolei Wang
Journal:  RSC Adv       Date:  2021-02-17       Impact factor: 3.361
  2 in total

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