| Literature DB >> 29094481 |
Marwa Abdallah1, Medhat El-Mofty2, Tag Anbar3, Hoda Rasheed2, Samia Esmat2, Amira Al-Tawdy2, Marwa M Fawzy2, Dalia Abdel-Halim2, Rehab Hegazy2, Heba Gawdat2, Dalia Bassiouny2, Mona A Ibrahim1, Iman Sany2, Mahy El-Bassiouny1, Mohamed Khalil1, Abeer Abdel-Aziz4, Zeinab M El Maadawi5, Wedad Z Mostafa2.
Abstract
This cross-sectional multicenter study aimed to evaluate serum CXCL-10, as an activity marker for vitiligo, and compare it with other putative serum and tissue markers. Serum CXCL-10 was compared to interferon gamma (IFN-γ), interleukin 6 (IL-6), and IL-17 using ELISA in 55 non-segmental vitiligo patients (30 active and 25 stable) and 30 healthy controls. Marginal skin biopsy was taken for immunohistochemical evaluation of CD8+T cells and CXCL-10+ve cells. Serum levels of CXCL-10, IL-17, and IL-6 were elevated in all vitiligo patients compared to controls (p < .05). All investigated serum markers were higher in active versus stable vitiligo. Tissue expression of CXCL-10+ve cells and CD8+ve T cells was stronger in vitiligo patients compared to controls, and tissue CXCL-10+ve cell expression was stronger in active versus stable cases. Positive correlations were noted between the different serum and tissue markers. CXCL-10 was the most specific, whereas IL-6 was the most sensitive serum marker to distinguish active from stable disease.Entities:
Keywords: CD8; CXCL-10; IFN-γ; IL-17; IL-6; activity markers; vitiligo
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Year: 2017 PMID： 29094481 DOI： 10.1111/pcmr.12667
Source DB: PubMed Journal: Pigment Cell Melanoma Res ISSN： 1755-1471 Impact factor: 4.693