Ying Wu1, Pu Ai2, Zisheng Ai3, Guotong Xu4. 1. Postdoctoral Research Station of Medicine, School of Medicine, Tongji University, Shanghai, China. Electronic address: wuying19890321@gmail.com. 2. Department of Clinic Medicine, Anhui Medical University, Hefei, China. Electronic address: 727249485@qq.com. 3. Department of Medical Statistics, School of Medicine, Tongji University, 1239 Siping Road, Yangpu District, Shanghai 200092, China. Electronic address: azs1966@126.com. 4. Tongji Eye Institute, School of Medicine, Tongji University, 1239 Siping Road, Yangpu District, Shanghai 200092, China. Electronic address: gtxu@tongji.edu.cn.
Abstract
AIMS: To assess the effects of laser photocoagulation as monotherapy or adjuvant therapy for the treatment of DME. METHODS: A search of the Cochrane Library, Pubmed, Embase, and the clinicaltrial.gov registry for randomized clinical trials comparing any two treatments of interest (SDMLP monotherapy, CLP monotherapy, CLP plus anti-VEGF therapy) was performed. Data were collected and pooled by Bayesian network meta-analyses which accounts for both direct and indirect comparisons. The primary outcome was the mean change in best-corrected visual acuity measured by the logarithm of the minimal angle of resolution units. The secondary outcome was the mean change in central macular thickness from baseline to month 12. RESULTS: Ranibizumab therapy combined with CLP was more effective than SDMLP alone (MD, -0.396; 95% CrI, -0.746 to -0.062) and CLP alone (MD, -0.621; 95% CrI, -0.823 to -0.431). There was no apparent difference of efficacy between SDMLP alone and CLP alone (MD, -0.225; 95% CrI, -0.501 to 0.058). There was no apparent difference of efficacy between SDMLP alone and Bevacizumab therapy combined with CLP (MD, -0.003, 95% CrI, -0.815 to 0.805). CONCLUSION: There was no apparent difference on improving vision between SDMLP monotherapy and CLP monotherapy. The most effective treatment in the network was ranibizumab therapy combined with CLP followed by SDMLP monotherapy, Bevacizumab therapy combined with CLP, and CLP monotherapy in rank order.
AIMS: To assess the effects of laser photocoagulation as monotherapy or adjuvant therapy for the treatment of DME. METHODS: A search of the Cochrane Library, Pubmed, Embase, and the clinicaltrial.gov registry for randomized clinical trials comparing any two treatments of interest (SDMLP monotherapy, CLP monotherapy, CLP plus anti-VEGF therapy) was performed. Data were collected and pooled by Bayesian network meta-analyses which accounts for both direct and indirect comparisons. The primary outcome was the mean change in best-corrected visual acuity measured by the logarithm of the minimal angle of resolution units. The secondary outcome was the mean change in central macular thickness from baseline to month 12. RESULTS:Ranibizumab therapy combined with CLP was more effective than SDMLP alone (MD, -0.396; 95% CrI, -0.746 to -0.062) and CLP alone (MD, -0.621; 95% CrI, -0.823 to -0.431). There was no apparent difference of efficacy between SDMLP alone and CLP alone (MD, -0.225; 95% CrI, -0.501 to 0.058). There was no apparent difference of efficacy between SDMLP alone and Bevacizumab therapy combined with CLP (MD, -0.003, 95% CrI, -0.815 to 0.805). CONCLUSION: There was no apparent difference on improving vision between SDMLP monotherapy and CLP monotherapy. The most effective treatment in the network was ranibizumab therapy combined with CLP followed by SDMLP monotherapy, Bevacizumab therapy combined with CLP, and CLP monotherapy in rank order.
Authors: Eliane C Jorge; Edson N Jorge; Mayra Botelho; Joyce G Farat; Gianni Virgili; Regina El Dib Journal: Cochrane Database Syst Rev Date: 2018-10-15
Authors: Stela Vujosevic; Caterina Toma; Edoardo Villani; Marco Brambilla; Emanuele Torti; Francesco Leporati; Andrea Muraca; Paolo Nucci; Stefano De Cilla Journal: Transl Vis Sci Technol Date: 2020-09-30 Impact factor: 3.283