Literature DB >> 29090939

Amycolamycins A and B, Two Enediyne-Derived Compounds from a Locust-Associated Actinomycete.

Shi Ying Ma1, Yong Sheng Xiao1, Bo Zhang1, Fen Li Shao1, Zhi Kai Guo2, Juan Juan Zhang1, Rui Hua Jiao1, Yang Sun1, Qiang Xu1, Ren Xiang Tan1,3, Hui Ming Ge1.   

Abstract

Two novel enediyne-derived natural products, amycolamycins A and B (1 and 2), were characterized from a locust-associated actinomycete Amycolatopsis sp. HCa4. Amycolamycins A and B contain a unique 2-(cyclopenta[a]inden-5-yl)oxirane core with suspected enediyne polyketide biosynthetic origin. Sequencing and analysis of the acm biosynthetic gene cluster allowed us to propose the biosynthetic pathway of 1 and 2. Moreover, amycolamycin A (1) was selectively cytotoxic to the M231 breast cancer cell line.

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Year:  2017        PMID： 29090939     DOI： 10.1021/acs.orglett.7b03113

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  7 in total

Review 1.  The secondary metabolites of rare actinomycetes: chemistry and bioactivity.

Authors:  Ting Ding; Luo-Jie Yang; Wei-Dong Zhang; Yun-Heng Shen
Journal:  RSC Adv       Date:  2019-07-16       Impact factor: 4.036

2.  Anti-MRSA Activity of Actinomycin X2 and Collismycin A Produced by Streptomyces globisporus WA5-2-37 From the Intestinal Tract of American Cockroach (Periplaneta americana).

Authors:  Zhiyu Chen; Peiyu Ou; Lingyan Liu; Xiaobao Jin
Journal:  Front Microbiol       Date:  2020-04-07       Impact factor: 5.640

Review 3.  Secondary Metabolites of the Genus Amycolatopsis: Structures, Bioactivities and Biosynthesis.

Authors:  Zhiqiang Song; Tangchang Xu; Junfei Wang; Yage Hou; Chuansheng Liu; Sisi Liu; Shaohua Wu
Journal:  Molecules       Date:  2021-03-26       Impact factor: 4.411

4.  Challenges and Opportunities to Develop Enediyne Natural Products as Payloads for Antibody-Drug Conjugates.

Authors:  Ajeeth Adhikari; Ben Shen; Christoph Rader
Journal:  Antib Ther       Date:  2021-01-12

5.  Zhaoshumycins A and B, Two Unprecedented Antimycin-Type Depsipeptides Produced by the Marine-Derived Streptomyces sp. ITBB-ZKa6.

Authors:  Zhikai Guo; Shiying Ma; Salman Khan; Hongjie Zhu; Bo Zhang; Shiqing Zhang; Ruihua Jiao
Journal:  Mar Drugs       Date:  2021-11-05       Impact factor: 5.118

6.  New Antibacterial Phenone Derivatives Asperphenone A-C from Mangrove-Derived Fungus Aspergillus sp. YHZ-1.

Authors:  Zhi-Kai Guo; Yi-Qin Zhou; Hao Han; Wen Wang; Lang Xiang; Xin-Zhao Deng; Hui-Ming Ge; Rui-Hua Jiao
Journal:  Mar Drugs       Date:  2018-01-30       Impact factor: 5.118

7.  Genome insights into the pharmaceutical and plant growth promoting features of the novel species Nocardia alni sp. nov.

Authors:  Imen Nouioui; Sung-Min Ha; Inwoo Baek; Jongsik Chun; Michael Goodfellow
Journal:  BMC Genomics       Date:  2022-01-21       Impact factor: 3.969
  7 in total

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