Camila Caram-Deelder1,2, Johanna G van der Bom1,2, Hein Putter3, Anja Leyte4, Daan van de Kerkhof5, Dorothea Evers1,6, Erik A Beckers7, Floor Weerkamp8, Francisca Hudig9, Jaap Jan Zwaginga1,6, Jan M M Rondeel10, Karen M K de Vooght11, Nathalie C V Péquériaux12, Otto Visser13, Jonathan P Wallis14, Rutger A Middelburg1,2. 1. Center for Clinical Transfusion Research, Sanquin Research, Leiden, the Netherlands. 2. Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands. 3. Department of Medical Statistics, Leiden University Medical Center, Leiden, the Netherlands. 4. Departments of Hematology and Clinical Chemistry, Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands. 5. Department of Clinical Chemistry and Hematology, Catharina Hospital, Eindhoven, the Netherlands. 6. Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands. 7. Department of Internal Medicine-Hematology, Maastricht University Medical Center, Maastricht, the Netherlands. 8. Department of Clinical Chemistry, Maasstad Ziekenhuis, Rotterdam, the Netherlands. 9. LabWest, Haga Teaching Hospital, The Hague, the Netherlands. 10. Department of Clinical Chemistry, Isala, Zwolle, the Netherlands. 11. Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, the Netherlands. 12. Department of Clinical Chemistry and Hematology, Jeroen Bosch Hospital, 's Hertogenbosch, the Netherlands. 13. Department of Hematology, VU Medical Center, Amsterdam, the Netherlands. 14. Department of Hematology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom.
Abstract
BACKGROUND: Storage time of platelet (PLT) concentrates has been negatively associated with clinical efficacy outcomes. The aim of this study was to quantify the association between storage time of PLT concentrates and interval to the next PLT transfusion for different types of PLT components, stored for up to 7 days and transfused to transfusion-dependent hematooncology patients with thrombocytopenia. STUDY DESIGN AND METHODS: From a cohort of patients from 10 major Dutch hospitals, patients were selected whose transfusion patterns were compatible with PLT transfusion dependency due to hematooncologic disease. Mean time to the next transfusion and mean differences in time to the next transfusion for different storage time categories (i.e., fresh, <4 days; intermediate, 4-5 days; and old, >5 days) were estimated, per component type, using multilevel mixed-effects linear models. RESULTS: Among a cohort of 29,761 patients who received 140,896 PLT transfusions we selected 4441 hematooncology patients who had received 12,724 PLT transfusions during periods of PLT transfusion dependency. Transfusion of fresh, compared to old, buffy coat-derived PLTs in plasma was associated with a delay to the next transfusion of 6.2 hours (95% confidence interval [CI], 4.5-8.0 hr). For buffy coat-derived PLTs in PAS-B and -C this difference was 7.7 hours (95% CI, 2.2-13.3 hr) and 3.9 hours (95% CI, -2.1 to 9.9 hr) while for apheresis PLTs in plasma it was only 1.8 hours (95% CI, -3.5 to 7.1 hr). CONCLUSION: Our results indicate that the time to the next transfusion shortens with increasing age of transfused buffy coat-derived PLT concentrates. This association was not observed for apheresis PLTs.
BACKGROUND: Storage time of platelet (PLT) concentrates has been negatively associated with clinical efficacy outcomes. The aim of this study was to quantify the association between storage time of PLT concentrates and interval to the next PLT transfusion for different types of PLT components, stored for up to 7 days and transfused to transfusion-dependent hematooncology patients with thrombocytopenia. STUDY DESIGN AND METHODS: From a cohort of patients from 10 major Dutch hospitals, patients were selected whose transfusion patterns were compatible with PLT transfusion dependency due to hematooncologic disease. Mean time to the next transfusion and mean differences in time to the next transfusion for different storage time categories (i.e., fresh, <4 days; intermediate, 4-5 days; and old, >5 days) were estimated, per component type, using multilevel mixed-effects linear models. RESULTS: Among a cohort of 29,761 patients who received 140,896 PLT transfusions we selected 4441 hematooncology patients who had received 12,724 PLT transfusions during periods of PLT transfusion dependency. Transfusion of fresh, compared to old, buffy coat-derived PLTs in plasma was associated with a delay to the next transfusion of 6.2 hours (95% confidence interval [CI], 4.5-8.0 hr). For buffy coat-derived PLTs in PAS-B and -C this difference was 7.7 hours (95% CI, 2.2-13.3 hr) and 3.9 hours (95% CI, -2.1 to 9.9 hr) while for apheresis PLTs in plasma it was only 1.8 hours (95% CI, -3.5 to 7.1 hr). CONCLUSION: Our results indicate that the time to the next transfusion shortens with increasing age of transfused buffy coat-derived PLT concentrates. This association was not observed for apheresis PLTs.
Authors: Meghan Delaney; Oliver Karam; Lani Lieberman; Katherine Steffen; Jennifer A Muszynski; Ruchika Goel; Scot T Bateman; Robert I Parker; Marianne E Nellis; Kenneth E Remy Journal: Pediatr Crit Care Med Date: 2022-01-01 Impact factor: 3.971