Andrea Ticinesi1,2, Angela Guerra3,4, Franca Allegri3,4, Antonio Nouvenne3,4, Gianfranco Cervellin5, Marcello Maggio3,4, Fulvio Lauretani3,4, Loris Borghi3,4, Tiziana Meschi3,4. 1. Department of Medicine and Surgery, University of Parma, Via Antonio Gramsci 14, 43126, Parma, Italy. andrea.ticinesi@unipr.it. 2. Dipartimento Medico Geriatrico-Riabilitativo, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy. andrea.ticinesi@unipr.it. 3. Department of Medicine and Surgery, University of Parma, Via Antonio Gramsci 14, 43126, Parma, Italy. 4. Dipartimento Medico Geriatrico-Riabilitativo, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy. 5. Dipartimento d'Emergenza Urgenza e Area Medica Generale e Specialistica, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy.
Abstract
BACKGROUND: The association of metabolic syndrome (MetS) traits with urinary calcium (UCE) or oxalate excretion (UOE) is uncertain in calcium stone formers (CSFs). Our aim was to investigate this association in a large group of Caucasian CSFs. METHODS: We retrospectively reviewed data of CSFs evaluated at our Kidney Stone Clinic from 1984 to 2015. Data on body mass index (BMI), MetS traits defined according to international consensus, family history of urolithiasis, anti-hypertensive treatments, calcemia, renal function, and 24-h urinary profile of lithogenic risk were collected. The association between MetS traits and UCE or UOE was tested with multivariate linear regression models accounting for a long list of potential confounders. RESULTS: We included 3003 CSFs, aged 44 ± 14 years. The prevalence of hypertension, diabetes, overweight (BMI ≥ 25 kg/m2) and dyslipidemia was 17, 2, 42 and 38%, respectively. Median values of UCE and UOE were 211 mg/24 h (IQR 143-296) and 28 mg/24 h (IQR 22-34), respectively. At a multivariate model, including age, sex, date of examination, drug treatments, family history, renal function, blood calcium and urinary factors as covariates, hypertension was a significant positive determinant of UCE (β ± SE 0.23 ± 0.07, p = 0.003), but overweight, dyslipidemia and diabetes were not. No MetS trait was significantly associated with UOE in multivariate models. CONCLUSIONS: In a large group of Caucasian CSFs, hypertension was the only MetS trait significantly associated with UCE, while no MetS trait was associated with oxalate excretion.
BACKGROUND: The association of metabolic syndrome (MetS) traits with urinary calcium (UCE) or oxalate excretion (UOE) is uncertain in calcium stone formers (CSFs). Our aim was to investigate this association in a large group of Caucasian CSFs. METHODS: We retrospectively reviewed data of CSFs evaluated at our Kidney Stone Clinic from 1984 to 2015. Data on body mass index (BMI), MetS traits defined according to international consensus, family history of urolithiasis, anti-hypertensive treatments, calcemia, renal function, and 24-h urinary profile of lithogenic risk were collected. The association between MetS traits and UCE or UOE was tested with multivariate linear regression models accounting for a long list of potential confounders. RESULTS: We included 3003 CSFs, aged 44 ± 14 years. The prevalence of hypertension, diabetes, overweight (BMI ≥ 25 kg/m2) and dyslipidemia was 17, 2, 42 and 38%, respectively. Median values of UCE and UOE were 211 mg/24 h (IQR 143-296) and 28 mg/24 h (IQR 22-34), respectively. At a multivariate model, including age, sex, date of examination, drug treatments, family history, renal function, blood calcium and urinary factors as covariates, hypertension was a significant positive determinant of UCE (β ± SE 0.23 ± 0.07, p = 0.003), but overweight, dyslipidemia and diabetes were not. No MetS trait was significantly associated with UOE in multivariate models. CONCLUSIONS: In a large group of Caucasian CSFs, hypertension was the only MetS trait significantly associated with UCE, while no MetS trait was associated with oxalate excretion.
Authors: I Alexandru Bobulescu; Naim M Maalouf; Giovanna Capolongo; Beverley Adams-Huet; Tara R Rosenthal; Orson W Moe; Khashayar Sakhaee Journal: Am J Physiol Renal Physiol Date: 2013-09-11
Authors: Antonio Nouvenne; Andrea Ticinesi; Angela Guerra; Giuseppina Folesani; Franca Allegri; Silvana Pinelli; Paolo Baroni; Mario Pedrazzoni; Giuseppe Lippi; Annalisa Terranegra; Elena Dogliotti; Laura Soldati; Loris Borghi; Tiziana Meschi Journal: J Transl Med Date: 2013-10-07 Impact factor: 5.531
Authors: Giovanni Gambaro; Emanuele Croppi; Fredric Coe; James Lingeman; Orson Moe; Elen Worcester; Noor Buchholz; David Bushinsky; Gary C Curhan; Pietro Manuel Ferraro; Daniel Fuster; David S Goldfarb; Ita Pfeferman Heilberg; Bernard Hess; John Lieske; Martino Marangella; Dawn Milliner; Glen M Preminger; Jose' Manuel Reis Santos; Khashayar Sakhaee; Kemal Sarica; Roswitha Siener; Pasquale Strazzullo; James C Williams Journal: J Nephrol Date: 2016-07-25 Impact factor: 3.902