Literature DB >> 29090376

Aging alters voltage-gated calcium channels in prefrontal cortex pyramidal neurons in the HIV brain.

Christina E Khodr1, Lihua Chen1, Lena Al-Harthi1, Xiu-Ti Hu2.   

Abstract

We assessed firing and voltage-gated Ca2+ influx in medial prefrontal cortex (mPFC) pyramidal neurons from older (12 months old) HIV-1 transgenic (Tg) rats. We found that neurons from older Tg rats showed increased firing compared to non-Tg rats, but Ca2+ spikes were unchanged. However, stronger excitatory stimulation was needed to evoke Ca2+ spikes, which was associated with reduced mPFC Cav1.2 L-type Ca2+ channel (L-channel) protein. In contrast, L-channel protein was unaltered in younger (6-7 weeks old) Tg rats, which we previously found had enhanced neuronal Ca2+ influx. These studies demonstrate that aging alters HIV-induced Ca2+ channel dysfunction that affects mPFC activity.

Entities:  

Keywords:  Calcium; HAND; HIV; HIV-1 Tg rat; L-channel; Medial prefrontal cortex

Mesh：

Substances：

Year:  2017        PMID： 29090376      PMCID： PMC6492926          DOI： 10.1007/s13365-017-0588-y

Source DB:  PubMed          Journal:  J Neurovirol        ISSN： 1355-0284            Impact factor:   2.643


  20 in total

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4.  HIV-Induced Hyperactivity of Striatal Neurons Is Associated with Dysfunction of Voltage-Gated Calcium and Potassium Channels at Middle Age.

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