Literature DB >> 29089656

Evaluation of the sterility of single-dose medications used in a multiple-dose fashion.

Elizabeth P Martin1, Jean Mukherjee1, Claire R Sharp1, Virginia B Sinnott-Stutzman1.   

Abstract

Bacterial proliferation was evaluated in single-dose medications used in a multi-dose fashion and when medications were intentionally inoculated with bacteria. Of 5 experimentally punctured medications, 1 of 75 vials (50% dextrose) became contaminated. When intentionally inoculated, hydroxyethyl starch and heparinized saline supported microbial growth. Based on these findings, it is recommended that hydroxyethyl starch and heparinized saline not be used in a multi-dose fashion.

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Year:  2017        PMID： 29089656      PMCID： PMC5640284     

Source DB:  PubMed          Journal:  Can Vet J        ISSN： 0008-5286            Impact factor:   1.008


  13 in total

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Authors:  Roy D Sleator; Colin Hill
Journal:  FEMS Microbiol Rev       Date:  2002-03       Impact factor: 16.408

Review 2.  Bacterial contamination of multiple-dose vials: a prevalence study.

Authors:  Frauke Mattner; Petra Gastmeier
Journal:  Am J Infect Control       Date:  2004-02       Impact factor: 2.918

Review 3.  APIC position paper: safe injection, infusion, and medication vial practices in health care.

Authors:  Susan A Dolan; Gwenda Felizardo; Sue Barnes; Tracy R Cox; Marcia Patrick; Katherine S Ward; Kathleen Meehan Arias
Journal:  Am J Infect Control       Date:  2010-04       Impact factor: 2.918

4.  Contamination of multiple-dose vials in a veterinary hospital.

Authors:  Catherine V Sabino; J Scott Weese
Journal:  Can Vet J       Date:  2006-08       Impact factor: 1.008

5.  The prevalence of multidose vial contamination by aerobic bacteria in a major teaching hospital, Shiraz, Iran, 2006.

Authors:  Mohammad Motamedifar; Mehrdad Askarian
Journal:  Am J Infect Control       Date:  2009-04-10       Impact factor: 2.918

Review 6.  Hospital epidemiology and infection control in acute-care settings.

Authors:  Emily R M Sydnor; Trish M Perl
Journal:  Clin Microbiol Rev       Date:  2011-01       Impact factor: 26.132

Review 7.  Assessment of infection control practices for interventional techniques: a best evidence synthesis of safe injection practices and use of single-dose medication vials.

Authors:  Laxmaiah Manchikanti; Frank J E Falco; Ramsin M Benyamin; David L Caraway; Standiford Helm Ii; Bradley W Wargo; Hans Hansen; Allan T Parr; Vijay Singh; Joshua A Hirsch
Journal:  Pain Physician       Date:  2012 Sep-Oct       Impact factor: 4.965

Review 8.  Pseudomonas aeruginosa: a formidable and ever-present adversary.

Authors:  K G Kerr; A M Snelling
Journal:  J Hosp Infect       Date:  2009-08-21       Impact factor: 3.926

9.  Outbreak of Serratia marcescens bloodstream and central nervous system infections after interventional pain management procedures.

Authors:  Adam L Cohen; Alison Ridpath; Judith Noble-Wang; Bette Jensen; Alicia M Peterson; Matt Arduino; Dan Jernigan; Arjun Srinivasan
Journal:  Clin J Pain       Date:  2008-06       Impact factor: 3.442

10.  Nasal carriage of Methicillin- and Mupirocin-resistant S. aureus among health care workers in a tertiary care hospital.

Authors:  Loveleena Agarwal; Amit Kumar Singh; Chandrim Sengupta; Amitabh Agarwal
Journal:  J Res Pharm Pract       Date:  2015 Oct-Dec
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