Literature DB >> 29089598

Cellular uptake of modified aminoglycosides.

Kaivin Hadidi1, Ezequiel Wexselblatt1, Jeffrey D Esko2, Yitzhak Tor1.   

Abstract

The uptake of modified amino- and guanidino-glycosides derived from kanamycin, tobramycin and neomycin in native and mutant CHO cells is examined using confocal microscopy and flow cytometry, illustrating the significance of multivalency for mammalian cell internalization of carriers that specifically interact with cell surface heparan sulfate proteoglycans.The Journal of Antibiotics advance online publication, 1 November 2017; doi:10.1038/ja.2017.131.

Entities:  

Year:  2017        PMID： 29089598     DOI： 10.1038/ja.2017.131

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  17 in total

1.  The history of antibiotics: the Japanese story.

Authors:  Joichi Kumazawa; Morimasu Yagisawa
Journal:  J Infect Chemother       Date:  2002-06       Impact factor: 2.211

Review 2.  Antibiotics that target protein synthesis.

Authors:  Lisa S McCoy; Yun Xie; Yitzhak Tor
Journal:  Wiley Interdiscip Rev RNA       Date:  2010-11-22       Impact factor: 9.957

3.  Aggregation-mediated macromolecular uptake by a molecular transporter.

Authors:  Makoto Inoue; Wenyong Tong; Jeffrey D Esko; Yitzhak Tor
Journal:  ACS Chem Biol       Date:  2013-04-26       Impact factor: 5.100

4.  Guanidinylated neomycin mediates heparan sulfate-dependent transport of active enzymes to lysosomes.

Authors:  Stéphane Sarrazin; Beth Wilson; William S Sly; Yitzhak Tor; Jeffrey D Esko
Journal:  Mol Ther       Date:  2010-05-04       Impact factor: 11.454

5.  Aminoglycoside-induced mutation suppression (stop codon readthrough) as a therapeutic strategy for Duchenne muscular dystrophy.

Authors:  Vinod Malik; Louise R Rodino-Klapac; Laurence Viollet; Jerry R Mendell
Journal:  Ther Adv Neurol Disord       Date:  2010-11       Impact factor: 6.570

6.  Cooperative, heparan sulfate-dependent cellular uptake of dimeric guanidinoglycosides.

Authors:  Andrew V Dix; Lucile Fischer; Stéphane Sarrazin; Christopher P H Redgate; Jeffrey D Esko; Yitzhak Tor
Journal:  Chembiochem       Date:  2010-11-02       Impact factor: 3.164

7.  Guanidinylated neomycin delivers large, bioactive cargo into cells through a heparan sulfate-dependent pathway.

Authors:  Lev Elson-Schwab; Omai B Garner; Manuela Schuksz; Brett E Crawford; Jeffrey D Esko; Yitzhak Tor
Journal:  J Biol Chem       Date:  2007-02-20       Impact factor: 5.157

Review 8.  Designer aminoglycosides: the race to develop improved antibiotics and compounds for the treatment of human genetic diseases.

Authors:  Mariana Hainrichson; Igor Nudelman; Timor Baasov
Journal:  Org Biomol Chem       Date:  2007-10-09       Impact factor: 3.876

9.  Cellular uptake of aminoglycosides, guanidinoglycosides, and poly-arginine.

Authors:  Nathan W Luedtke; Peter Carmichael; Yitzhak Tor
Journal:  J Am Chem Soc       Date:  2003-10-15       Impact factor: 15.419

10.  On guanidinium and cellular uptake.

Authors:  Ezequiel Wexselblatt; Jeffrey D Esko; Yitzhak Tor
Journal:  J Org Chem       Date:  2014-07-21       Impact factor: 4.354
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