Literature DB >> 2908948

Ketoconazole: a possible direct cytotoxic effect on prostate carcinoma cells.

T Eichenberger1, J Trachtenberg, P Toor, A Keating.   

Abstract

Ketoconazole has been recently used in the treatment of advanced prostatic cancer and is believed to exert its effect by inhibition of androgen production. In order to determine whether ketoconazole exerts an additional direct cytotoxic effect on prostate cancer cells, we studied its effect on human hormone-independent prostate cancer cell lines (PC-3 and DU-145) in an in vitro clonogenic tumor assay. We showed that clinically achievable doses of ketoconazole caused greater than 90% suppression of tumor colony growth.

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Year:  1989        PMID： 2908948     DOI： 10.1016/s0022-5347(17)40639-2

Source DB:  PubMed          Journal:  J Urol        ISSN： 0022-5347            Impact factor:   7.450


  9 in total

Review 1.  [What comes after docetaxel?].

Authors:  C-H Ohlmann; M Stöckle
Journal:  Urologe A       Date:  2010-01       Impact factor: 0.639

Review 2.  [Third generation anti-androgen therapy of advanced prostate cancer].

Authors:  C-H Ohlmann; J Kamradt; M Stöckle
Journal:  Urologe A       Date:  2012-04       Impact factor: 0.639

Review 3.  Use of androgen deprivation therapy in prostate cancer: indications and prevalence.

Authors:  Roisin M Connolly; Michael A Carducci; Emmanuel S Antonarakis
Journal:  Asian J Androl       Date:  2012-01-09       Impact factor: 3.285

Review 4.  Treatment options in hormone-refractory prostate cancer: current and future approaches.

Authors:  K A Harris; D M Reese
Journal:  Drugs       Date:  2001       Impact factor: 9.546

5.  Enhanced Interaction between Warfarin and High-Dose Ketoconazole: A Case Report.

Authors:  Cynthia A Jackevicius; Mannhu N Ton
Journal:  Case Rep Med       Date:  2009-12-09

6.  Analysis of the cytotoxic effects of ruthenium-ketoconazole and ruthenium-clotrimazole complexes on cancer cells.

Authors:  Elisa Robles-Escajeda; Alberto Martínez; Armando Varela-Ramirez; Roberto A Sánchez-Delgado; Renato J Aguilera
Journal:  Cell Biol Toxicol       Date:  2013-11-24       Impact factor: 6.691

Review 7.  Hormonal Therapy for Prostate Cancer.

Authors:  Kunal Desai; Jeffrey M McManus; Nima Sharifi
Journal:  Endocr Rev       Date:  2021-05-25       Impact factor: 19.871

8.  Prospective evaluation of low-dose ketoconazole plus hydrocortisone in docetaxel pre-treated castration-resistant prostate cancer patients.

Authors:  E N Lo; L A Beckett; C X Pan; D Robles; J M Suga; J M Sands; P N Lara
Journal:  Prostate Cancer Prostatic Dis       Date:  2015-02-10       Impact factor: 5.554

9.  Dihydrotestosterone synthesis pathways from inactive androgen 5α-androstane-3β,17β-diol in prostate cancer cells: Inhibition of intratumoural 3β-hydroxysteroid dehydrogenase activities by abiraterone.

Authors:  Takashi Ando; Tsutomu Nishiyama; Itsuhiro Takizawa; Fumio Ishizaki; Yoshimichi Miyashiro; Keisuke Takeda; Noboru Hara; Yoshihiko Tomita
Journal:  Sci Rep       Date:  2016-08-26       Impact factor: 4.379
  9 in total

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