R Killey1, C Mynors1, R Pearce1, A Nell2, A Prentis3, M J Day4. 1. Moreton Morrell College, Moreton Morrell, Warwickshire, CV35 9BL, UK. 2. Medivet, Watford, Hertfordshire, WD24 7UY, UK. 3. Hyde Park Veterinary Centre, London, W2 2AE, UK. 4. School of Veterinary Sciences, University of Bristol, Langford, North Somerset, BS40 5DU, UK.
Abstract
OBJECTIVES: To determine the utility of an in-practice test kit to detect protective serum antibody against canine distemper virus, canine adenovirus and canine parvovirus type 2 in a sample of the UK dog population. MATERIALS AND METHODS: Serum samples from 486 dogs, last vaccinated between less than 1 month and 124 months previously, were tested with the VacciCheck™ test kit for protective antibodies against distemper, adenovirus and parvovirus type 2. RESULTS: A high proportion of the dogs tested (93·6%) had protective antibody against all three of the core vaccine antigens: 95·7% of the dogs were seropositive against canine distemper virus, 97·3% against canine adenovirus and 98·5% against canine parvovirus type 2. The small number of dogs that were seronegative for one or more of the antigens (n = 31) may have had waning of previous serum antibody or may have been rare genetic non-responders to that specific antigen. CLINICAL SIGNIFICANCE: UK veterinarians can be reassured that triennial revaccination of adult dogs with core vaccines provides long-lived protective immunity. In-practice serological test kits are a valuable tool for informing decision-making about canine core revaccination.
OBJECTIVES: To determine the utility of an in-practice test kit to detect protective serum antibody against canine distemper virus, canine adenovirus and canine parvovirus type 2 in a sample of the UK dog population. MATERIALS AND METHODS: Serum samples from 486 dogs, last vaccinated between less than 1 month and 124 months previously, were tested with the VacciCheck™ test kit for protective antibodies against distemper, adenovirus and parvovirus type 2. RESULTS: A high proportion of the dogs tested (93·6%) had protective antibody against all three of the core vaccine antigens: 95·7% of the dogs were seropositive against canine distemper virus, 97·3% against canine adenovirus and 98·5% against canine parvovirus type 2. The small number of dogs that were seronegative for one or more of the antigens (n = 31) may have had waning of previous serum antibody or may have been rare genetic non-responders to that specific antigen. CLINICAL SIGNIFICANCE: UK veterinarians can be reassured that triennial revaccination of adult dogs with core vaccines provides long-lived protective immunity. In-practice serological test kits are a valuable tool for informing decision-making about canine core revaccination.
Authors: Herman Egberink; Tadeusz Frymus; Katrin Hartmann; Karin Möstl; Diane D Addie; Sándor Belák; Corine Boucraut-Baralon; Regina Hofmann-Lehmann; Albert Lloret; Fulvio Marsilio; Maria Grazia Pennisi; Séverine Tasker; Etienne Thiry; Uwe Truyen; Margaret J Hosie Journal: Viruses Date: 2022-07-22 Impact factor: 5.818