| Literature DB >> 29087519 |
Lin Zeng1,2, Chen Ming3,4, Yan Li1,5, Ling-Yan Su2,6, Yan-Hua Su7, Newton O Otecko1,2,8, Ambroise Dalecky9,10, Stephen Donnellan11, Ken Aplin12, Xiao-Hui Liu13, Ying Song13, Zhi-Bin Zhang14, Ali Esmailizadeh15, Saeed S Sohrabi15, Hojjat Asadollahpour Nanaei15, He-Qun Liu1,2, Ming-Shan Wang1,2, Solimane Ag Atteynine16,17, Gérard Rocamora18, Fabrice Brescia19, Serge Morand20, David M Irwin1,21, Ming-Sheng Peng1,2,8, Yong-Gang Yao2,6, Hai-Peng Li3, Dong-Dong Wu1,2,8, Ya-Ping Zhang1,2,5.
Abstract
The geographic origin and migration of the brown rat (Rattus norvegicus) remain subjects of considerable debate. In this study, we sequenced whole genomes of 110 wild brown rats with a diverse world-wide representation. We reveal that brown rats migrated out of southern East Asia, rather than northern Asia as formerly suggested, into the Middle East and then to Europe and Africa, thousands of years ago. Comparison of genomes from different geographical populations reveals that many genes involved in the immune system experienced positive selection in the wild brown rat.Entities:
Keywords: Rattus norvegicus; demographic history; natural selection; origin
Mesh：
Year: 2018 PMID： 29087519 DOI： 10.1093/molbev/msx276
Source DB: PubMed Journal: Mol Biol Evol ISSN： 0737-4038 Impact factor: 16.240