Literature DB >> 29087482

Severity of Disease in Humanized Mice Infected With Ebola Virus or Reston Virus Is Associated With Magnitude of Early Viral Replication in Liver.

Jessica R Spengler1, Greg Saturday2, Kerry J Lavender3, Cynthia Martellaro4, James G Keck5, Stuart T Nichol1, Christina F Spiropoulou1, Heinz Feldmann4, Joseph Prescott4,6.   

Abstract

Both Ebola virus (EBOV) and Reston virus (RESTV) cause disease in nonhuman primates, yet only EBOV causes disease in humans. To investigate differences in viral pathogenicity, humanized mice (hu-NSG-SGM3) were inoculated with EBOV or RESTV. Consistent with differences in disease in human infection, pronounced weight loss and markers of hepatic damage and disease were observed exclusively in EBOV-infected mice. These abnormalities were associated with significantly higher EBOV replication in the liver but not in the spleen, suggesting that in this model, efficiency of viral replication in select tissues early in infection may contribute to differences in viral pathogenicity.
© The Author(s) 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  Ebola virus; NSG-SGM3; Reston virus; hemorrhagic fever; humanized mice

Mesh：

Year:  2017        PMID： 29087482      PMCID： PMC5853858          DOI： 10.1093/infdis/jix562

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


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Review 10.  The Utility of Human Immune System Mice for High-Containment Viral Hemorrhagic Fever Research.

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