Literature DB >> 29085959

Insulin-like growth factor-6 (IGFBP-6) stimulates neutrophil oxidative burst, degranulation and chemotaxis.

Massimo Conese1, Susanna D'Oria2, Stefano Castellani3, Rosa Trotta3, Pasqualina Montemurro2, Arcangelo Liso4.   

Abstract

The aim of this study was to understand whether insulin-like growth factor-binding protein-6 (IGFBP-6) has functional effects on neutrophils, in particular when they cross epithelium during inflammation. We found that IGFBP-6 increased ROS production (cytofluorimetry), degranulation of primary and tertiary granules (ELISA) and transmigration through the epithelial monolayer. No priming by IGFBP-6 on neutrophils stimulated by either PMA or fMLP was observed. IGFBP-6 is an agonist of neutrophils' functions, most likely when these cells have been already activated by other stimuli.

Entities:  

Keywords:  Chemotaxis; Degranulation; IGFBP-6; Neutrophils; Oxidative burst

Mesh：

Substances：

Year:  2017        PMID： 29085959     DOI： 10.1007/s00011-017-1107-6

Source DB:  PubMed          Journal:  Inflamm Res        ISSN： 1023-3830            Impact factor:   4.575


  13 in total

Review 1.  Neutrophil priming: pathophysiological consequences and underlying mechanisms.

Authors:  A M Condliffe; E Kitchen; E R Chilvers
Journal:  Clin Sci (Lond)       Date:  1998-05       Impact factor: 6.124

2.  CFTR-dependent chloride efflux in cystic fibrosis mononuclear cells is increased by ivacaftor therapy.

Authors:  Lorenzo Guerra; Susanna D'Oria; Maria Favia; Stefano Castellani; Teresa Santostasi; Angela M Polizzi; Maria A Mariggiò; Crescenzio Gallo; Valeria Casavola; Pasqualina Montemurro; Giuseppina Leonetti; Antonio Manca; Massimo Conese
Journal:  Pediatr Pulmonol       Date:  2017-04-26

3.  Cross-talk between MAP kinase pathways is involved in IGF-independent, IGFBP-6-induced Rh30 rhabdomyosarcoma cell migration.

Authors:  Ping Fu; Guang Jun Liang; Sahil S Khot; Robert Phan; Leon A Bach
Journal:  J Cell Physiol       Date:  2010-09       Impact factor: 6.384

4.  Effect of phorbol myristate acetate on the oxidative metabolism of human polymorphonuclear leukocytes.

Authors:  L R DeChatelet; P S Shirley; R B Johnston
Journal:  Blood       Date:  1976-04       Impact factor: 22.113

5.  Recent insights into the actions of IGFBP-6.

Authors:  Leon A Bach
Journal:  J Cell Commun Signal       Date:  2015-03-26       Impact factor: 5.782

Review 6.  Insulin-like growth factor-binding protein-6 and cancer.

Authors:  Leon A Bach; Ping Fu; Zhiyong Yang
Journal:  Clin Sci (Lond)       Date:  2013-02       Impact factor: 6.124

7.  Promotion of cancer cell migration: an insulin-like growth factor (IGF)-independent action of IGF-binding protein-6.

Authors:  Ping Fu; Julian A Thompson; Leon A Bach
Journal:  J Biol Chem       Date:  2007-05-22       Impact factor: 5.157

Review 8.  Neutrophil cell surface receptors and their intracellular signal transduction pathways.

Authors:  Krisztina Futosi; Szabina Fodor; Attila Mócsai
Journal:  Int Immunopharmacol       Date:  2013-08-30       Impact factor: 4.932

9.  Insulin-Like Growth Factor Binding Protein 6 in Rheumatoid Arthritis: A Possible Novel Chemotactic Factor?

Authors:  Alessia Alunno; Onelia Bistoni; Mirko Manetti; Giacomo Cafaro; Valentina Valentini; Elena Bartoloni; Roberto Gerli; Arcangelo Liso
Journal:  Front Immunol       Date:  2017-05-18       Impact factor: 7.561

10.  Human monocyte-derived dendritic cells exposed to hyperthermia show a distinct gene expression profile and selective upregulation of IGFBP6.

Authors:  Arcangelo Liso; Stefano Castellani; Francesca Massenzio; Rosa Trotta; Alessandra Pucciarini; Barbara Bigerna; Pasquale De Luca; Pietro Zoppoli; Filippo Castiglione; Maria Concetta Palumbo; Fabrizio Stracci; Matteo Landriscina; Giorgina Specchia; Leon A Bach; Massimo Conese; Brunangelo Falini
Journal:  Oncotarget       Date:  2017-06-01
View more
  5 in total

Review 1.  IGFBP-6: At the Crossroads of Immunity, Tissue Repair and Fibrosis.

Authors:  Arcangelo Liso; Santina Venuto; Anna Rita Daniela Coda; Cesarina Giallongo; Giuseppe Alberto Palumbo; Daniele Tibullo
Journal:  Int J Mol Sci       Date:  2022-04-14       Impact factor: 6.208

Review 2.  The Roles of Insulin-Like Growth Factor Binding Protein Family in Development and Diseases.

Authors:  Fei Song; Xiao-Xia Zhou; Yu Hu; Gang Li; Yan Wang
Journal:  Adv Ther       Date:  2020-12-17       Impact factor: 3.845

3.  Insulin-Like Growth Factor Binding Protein 6 Is Secreted in Extracellular Vesicles upon Hyperthermia and Oxidative Stress in Dendritic Cells But Not in Monocytes.

Authors:  Massimo Conese; Lorenzo Pace; Nicoletta Pignataro; Lucia Catucci; Antonio Ambrosi; Sante Di Gioia; Nicola Tartaglia; Arcangelo Liso
Journal:  Int J Mol Sci       Date:  2020-06-22       Impact factor: 5.923

Review 4.  From fever to immunity: A new role for IGFBP-6?

Authors:  Arcangelo Liso; Nazzareno Capitanio; Roberto Gerli; Massimo Conese
Journal:  J Cell Mol Med       Date:  2018-08-17       Impact factor: 5.310

5.  Insulin-Like Growth Factor Binding Protein (IGFBP-6) as a Novel Regulator of Inflammatory Response in Cystic Fibrosis Airway Cells.

Authors:  Onofrio Laselva; Maria Laura Criscione; Caterina Allegretta; Sante Di Gioia; Arcangelo Liso; Massimo Conese
Journal:  Front Mol Biosci       Date:  2022-07-12
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.