Literature DB >> 29085635

A rare case of three-way complex variant translocation in chronic myeloid leukemia t(6;9;22)(p21;q34;q11): A case report.

Muhammad Asif1, Abrar Hussain1, Abdul Wali1, Nazeer Ahmad1, Naheed Sajjad2, Muhammad Amir1, Irfan Ali3, Peter Natesan Pushparaj4, Mahmood Rasool4.   

Abstract

Philadelphia (Ph)-positive chromosome or Ph translocation has been recognized in 90-95 chronic myeloid leukemia (CML) cases worldwide. However, only 5-8% CML patients show complex variant translocations. In the present study, hematological tests for a 47-year-old female CML patient were performed to determine the hemoglobin, platelets and total leukocyte values. A FISH test was carried out to recognize the BCR/ABL gene fusion, and a cytogenetic analysis was performed. The hematological results showed an increase in WBC (414000/mm3) and a decrease in hemoglobin (8.9 mg/dl), indicating the anemic condition in the CML patient. Furthermore, cytogenetic karyotyping results showed 46,XX,t(6;9;22)(p21;q34;q11) and positive for Ph chromosome. In conclusion, in the present study, we report a rare three-way complex variant translocation in a CML patient.

Entities:  

Keywords:  Philadelphia chromosome; chronic myeloid leukemia; imatinib mesylate; variant complex translocation

Year:  2017        PMID： 29085635      PMCID： PMC5649580          DOI： 10.3892/br.2017.967

Source DB:  PubMed          Journal:  Biomed Rep        ISSN： 2049-9434


  29 in total

1.  Complex translocation t(6;9;22)(p21.1;q34;q11) at diagnosis is a therapy resistance index in chronic myeloid leukaemia.

Authors:  Enrico Orciuolo; Gabriele Buda; Sara Galimberti; Giulia Cervetti; Nadia Cecconi; Federico Papineschi; Mario Petrini
Journal:  Leuk Res       Date:  2007-04-05       Impact factor: 3.156

2.  Philadelphia-positive acute lymphoblastic leukemia with multiple subclones including duplication of the Philadelphia chromosome and Abelson oncogene.

Authors:  Roberta La Starza; Antonella Vitale; Anna Serra; Giuseppe Saglio; Giuseppe Fioritoni; Daniela Falzetti; Massimo F Martelli; Robin Foà; Cristina Mecucci
Journal:  Cancer Genet Cytogenet       Date:  2002-01-01

Review 3.  Chronic myeloid leukemia: diagnosis and treatment.

Authors:  Alfonso Quintás-Cardama; Jorge E Cortes
Journal:  Mayo Clin Proc       Date:  2006-07       Impact factor: 7.616

4.  Variant Philadelphia translocations in CML: correlation with fragile sites.

Authors:  M Sessarego; R Defferrari; C Panarello; F Frassoni; P Mandich; F Ajmar
Journal:  Cancer Genet Cytogenet       Date:  1988-03

5.  Multicolor COBRA-FISH analysis of chronic myeloid leukemia reveals novel cryptic balanced translocations during disease progression.

Authors:  Aikaterini Barbouti; Bertil Johansson; Mattias Höglund; Nils Mauritzson; Bodil Strömbeck; Per-Gunnar Nilsson; Hans J Tanke; Anne Hagemeijer; Felix Mitelman; Thoas Fioretos
Journal:  Genes Chromosomes Cancer       Date:  2002-10       Impact factor: 5.006

6.  Cytogenetic response to imatinib treatment in Southern Brazilian patients with chronic myelogenous leukemia and variant Philadelphia chromosome.

Authors:  Dayane B Koshiyama; Marcelo E Z Capra; Giorgio A Paskulin; Rafael F M Rosa; Ceres A V Oliveira; Tito Vanelli; Laura M Fogliatto; Paulo R G Zen
Journal:  Ann Hematol       Date:  2012-10-14       Impact factor: 3.673

7.  A rare chronic myeloid leukemia case with Philadelphia chromosome, BCR-ABL e13a3 transcript and complex translocation involving four different chromosomes.

Authors:  Walid Al Achkar; Abdulsamad Wafa; Bashar Yousef Ali; Marina Manvelyan; Thomas Liehr
Journal:  Oncol Lett       Date:  2010-09-01       Impact factor: 2.967

8.  Poorly differentiated extraskeletal myxoid chondrosarcoma with t(9;22)(q22;q11) translocation presenting initially as a solid variant devoid of myxoid areas.

Authors:  Robin Reid; M Vipula Chandu de Silva; Lindsay Paterson
Journal:  Int J Surg Pathol       Date:  2003-04       Impact factor: 1.271

9.  Contribution of fluorescence in situ hybridization analyses to the characterization of masked and complex Philadelphia chromosome translocations in chronic myelocytic leukemia.

Authors:  F Morel; A Herry; M-J Le Bris; P Morice; P Bouquard; J-F Abgrall; C Berthou; M De Braekeleer
Journal:  Cancer Genet Cytogenet       Date:  2003-12

10.  A new t(9;11;20;22)(q34;p11.2;q11.21;q11) in a Philadelphia-positive chronic myeloid leukemia case.

Authors:  Walid Al-Achkar; Abdulsamad Wafa; Thomas Liehr
Journal:  Oncol Lett       Date:  2012-11-21       Impact factor: 2.967
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  3 in total

1.  Management of chronic myeloid leukemia presenting with isolated thrombocytosis and complex Philadelphia chromosome: A case report.

Authors:  Lu Gao; Ming-Qiang Ren; Zu-Guo Tian; Zhi-Yuan Peng; Genghui Shi; Zhong Yuan
Journal:  Medicine (Baltimore)       Date:  2021-09-03       Impact factor: 1.817

2.  Molecular, Cytogenetic, and Hematological Analysis of Chronic Myeloid Leukemia Patients and Discovery of Two Novel Translocations.

Authors:  Muhammad Asif; Abrar Hussain; Abdul Wali; Nazeer Ahmed; Irfan Ali; Zafar Iqbal; Muhammad Amir; Muhammad Shafiq; Mahmood Rasool
Journal:  Anal Cell Pathol (Amst)       Date:  2021-08-12       Impact factor: 2.916

3.  A Unique Three-Way Variant Philadelphia Chromosome t(6;9;22)(p21.3;q34;q11.2) in a Newly Diagnosed Patient with Chronic Myeloid Leukemia Responded to Flumatinib.

Authors:  Lili Chen; Junling Zhang; Na Yang; Ningping Tan; Di Meng; Fei Zhang; Yuyang Qi; Guangqi Wu; Zhenyu Li
Journal:  Onco Targets Ther       Date:  2022-09-20       Impact factor: 4.345
  3 in total

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