Literature DB >> 29084741

Mutations at the Ribosomal S10 Gene in Clinical Strains of Staphylococcus aureus with Reduced Susceptibility to Tigecycline.

M Angeles Argudín1, S Roisin2, M Dodémont2, C Nonhoff2, A Deplano2, O Denis2,3.   

Abstract

Mutations on the tip of the extended loop of the ribosomal S10 protein have been associated to tigecycline (TGC) resistance in passaged mutants of different bacteria species. This study described the first two clinical TGC-resistant Staphylococcus aureus isolates with these mutations. One strain (TGC MIC = 2 mg/liter) had a 12-nucleotide deletion affecting residues 56 to 59 (HKYK) of the S10 protein. The second strain (TGC MIC = 1 mg/liter) had amino acid substitutions (K57M and Y58F) previously described in S. aureus passaged mutants.
Copyright © 2017 American Society for Microbiology.

Entities:  

Keywords:  BORSA; MepA; rpsJ

Mesh：

Substances：

Year:  2017        PMID： 29084741      PMCID： PMC5740382          DOI： 10.1128/AAC.01852-17

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  9 in total

1.  Presence of tetracycline resistance determinants and susceptibility to tigecycline and minocycline.

Authors:  Ad C Fluit; Alice Florijn; Jan Verhoef; Dana Milatovic
Journal:  Antimicrob Agents Chemother       Date:  2005-04       Impact factor: 5.191

2.  Functional consequences of substitution mutations in MepR, a repressor of the Staphylococcus aureus MepA multidrug efflux pump gene.

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Journal:  J Bacteriol       Date:  2013-06-07       Impact factor: 3.490

3.  Rampant Parasexuality Evolves in a Hospital Pathogen during Antibiotic Selection.

Authors:  Kathryn Beabout; Troy G Hammerstrom; Tim T Wang; Minny Bhatty; Peter J Christie; Gerda Saxer; Yousif Shamoo
Journal:  Mol Biol Evol       Date:  2015-06-09       Impact factor: 16.240

4.  Mutagenesis and modeling to predict structural and functional characteristics of the Staphylococcus aureus MepA multidrug efflux pump.

Authors:  Bryan D Schindler; Diixa Patel; Susan M Seo; Glenn W Kaatz
Journal:  J Bacteriol       Date:  2012-11-21       Impact factor: 3.490

5.  Structural characterization of MepB from Staphylococcus aureus reveals homology to endonucleases.

Authors:  Sayeh Agah; Sandra Poulos; Christian Banchs; Salem Faham
Journal:  Protein Sci       Date:  2014-03-11       Impact factor: 6.725

6.  The ribosomal S10 protein is a general target for decreased tigecycline susceptibility.

Authors:  Kathryn Beabout; Troy G Hammerstrom; Anisha Maria Perez; Bárbara Freitas Magalhães; Amy G Prater; Thomas P Clements; Cesar A Arias; Gerda Saxer; Yousif Shamoo
Journal:  Antimicrob Agents Chemother       Date:  2015-06-29       Impact factor: 5.191

7.  Tigecycline resistance in clinical isolates of Enterococcus faecium is mediated by an upregulation of plasmid-encoded tetracycline determinants tet(L) and tet(M).

Authors:  S Fiedler; J K Bender; I Klare; S Halbedel; E Grohmann; U Szewzyk; G Werner
Journal:  J Antimicrob Chemother       Date:  2015-12-18       Impact factor: 5.790

8.  A novel MATE family efflux pump contributes to the reduced susceptibility of laboratory-derived Staphylococcus aureus mutants to tigecycline.

Authors:  Fionnuala McAleese; Peter Petersen; Alexey Ruzin; Paul M Dunman; Ellen Murphy; Steven J Projan; Patricia A Bradford
Journal:  Antimicrob Agents Chemother       Date:  2005-05       Impact factor: 5.191

9.  Potential of Tetracycline Resistance Proteins To Evolve Tigecycline Resistance.

Authors:  Marius Linkevicius; Linus Sandegren; Dan I Andersson
Journal:  Antimicrob Agents Chemother       Date:  2015-11-23       Impact factor: 5.191
  9 in total
  8 in total

1.  Effects of Ribosomal Protein S10 Flexible Loop Mutations on Tetracycline and Tigecycline Susceptibility of Escherichia coli.

Authors:  Norbert Izghirean; Claudia Waidacher; Clemens Kittinger; Miriam Chyba; Günther Koraimann; Brigitte Pertschy; Gernot Zarfel
Journal:  Front Microbiol       Date:  2021-06-18       Impact factor: 5.640

2.  Eravacycline susceptibility was impacted by genetic mutation of 30S ribosome subunits, and branched-chain amino acid transport system II carrier protein, Na/Pi cotransporter family protein in Staphylococcus aureus.

Authors:  Zhanwen Wang; Zhiwei Lin; Bing Bai; Guangjian Xu; Peiyu Li; Zhijian Yu; Qiwen Deng; Yongpeng Shang; Jinxin Zheng
Journal:  BMC Microbiol       Date:  2020-07-01       Impact factor: 3.605

Review 3.  Streptomyces as a Prominent Resource of Future Anti-MRSA Drugs.

Authors:  Hefa Mangzira Kemung; Loh Teng-Hern Tan; Tahir Mehmood Khan; Kok-Gan Chan; Priyia Pusparajah; Bey-Hing Goh; Learn-Han Lee
Journal:  Front Microbiol       Date:  2018-09-24       Impact factor: 5.640

4.  Eravacycline activity against clinical S. aureus isolates from China: in vitro activity, MLST profiles and heteroresistance.

Authors:  Fan Zhang; Bing Bai; Guang-Jian Xu; Zhi-Wei Lin; Gui-Qiu Li; Zhong Chen; Hang Cheng; Xiang Sun; Hong-Yan Wang; Yan-Wei Chen; Jin-Xin Zheng; Qi-Wen Deng; Zhi-Jian Yu
Journal:  BMC Microbiol       Date:  2018-12-13       Impact factor: 3.605

5.  Prevalence of tet(X4) in Escherichia coli From Duck Farms in Southeast China.

Authors:  Yang Yu; Chao-Yue Cui; Xu Kuang; Chong Chen; Min-Ge Wang; Xiao-Ping Liao; Jian Sun; Ya-Hong Liu
Journal:  Front Microbiol       Date:  2021-08-23       Impact factor: 5.640

6.  In vitro Activity and Heteroresistance of Omadacycline Against Clinical Staphylococcus aureus Isolates From China Reveal the Impact of Omadacycline Susceptibility by Branched-Chain Amino Acid Transport System II Carrier Protein, Na/Pi Cotransporter Family Protein, and Fibronectin-Binding Protein.

Authors:  Bing Bai; Zhiwei Lin; Zhangya Pu; Guangjian Xu; Fan Zhang; Zhong Chen; Xiang Sun; Jinxin Zheng; Peiyu Li; Qiwen Deng; Zhijian Yu
Journal:  Front Microbiol       Date:  2019-11-08       Impact factor: 5.640

7.  Novel Tet(L) Efflux Pump Variants Conferring Resistance to Tigecycline and Eravacycline in Staphylococcus Spp.

Authors:  Nannan Wang; Dexi Li; Stefan Schwarz; Shangshang Qin; Hong Yao; Xiang-Dang Du
Journal:  Microbiol Spectr       Date:  2021-12-08

8.  Coagulase-negative staphylococci: a 20-year study on the antimicrobial resistance profile of blood culture isolates from a teaching hospital.

Authors:  Valéria Cataneli Pereira; Letícia Calixto Romero; Luiza Pinheiro-Hubinger; Adilson Oliveira; Katheryne Benini Martins; Maria de Lourdes Ribeiro de Souza da Cunha
Journal:  Braz J Infect Dis       Date:  2020-02-19       Impact factor: 3.257
  8 in total

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