Kiran Shekar1, Daniel Brodie2, John Fraser3, Graeme MacLaren4. 1. Adult Intensive Care Services and Critical Care Research Group, Prince Charles Hospital; and Centre of Research Excellence for Advanced Cardio-respiratory Therapies Improving Organ Support (ACTIONS) and the University of Queensland, Brisbane, QLD, Australia. kiran.shekar@health.qld.gov.au. 2. Columbia College of Physicians and Surgeons/New York-Presbyterian Hospital, New York, NY, United States. 3. Adult Intensive Care Services and Critical Care Research Group, Prince Charles Hospital; and Centre of Research Excellence for Advanced Cardio-respiratory Therapies Improving Organ Support (ACTIONS) and the University of Queensland, Brisbane, QLD, Australia. 4. Cardiothoracic Intensive Care Unit, National University Health System Singapore; and Paediatric Intensive Care Unit, Department of Paediatrics, Royal Children's Hospital, University of Melbourne, Melbourne, VIC, Australia.