Yoon Kyoung So1, Dongryul Oh2, Nayeon Choi3, Chung-Hwan Baek3, Yong Chan Ahn2, Man Ki Chung3. 1. Department of Otorhinolaryngology - Head and Neck Surgery, Inje University College of Medicine, Ilsan Paik Hospital, Goyang-Si, Korea. 2. Department of Radiation Oncology, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea. 3. Department of Otorhinolaryngology - Head and Neck Surgery, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea.
Abstract
BACKGROUND: The purpose of this study was to investigate whether adjuvant radiotherapy (RT) is efficacious for regional control and survival in patients with pN0 oral tongue cancer. METHODS: Clinicopathological features of 166 patients with pN0 oral tongue cancer were compared between those who underwent adjuvant RT to the neck (neck RT-positive) and those who did not (neck RT-negative). Study endpoints were isolated regional recurrence and 3-year regional recurrence-free survival (RRFS). Propensity score matching was also performed. RESULTS: Cox regression analysis did not reveal any significant predictor of isolated regional recurrence, including RT field. Three-year RRFS showed modest improvement in neck RT-positive group compared to neck RT-negative group before (92.2% vs 91.9%) and after propensity analysis (93.8% vs 83.3%), without statistical significance (log-rank P = .85 and .37, respectively). CONCLUSION: Despite more frequent unfavorable factors, the neck RT-positive group had a comparable oncologic outcome to the neck RT-negative group, suggesting that a marginal benefit in regional control might be expected from extending the RT field to the neck for pN0 oral tongue cancer.
BACKGROUND: The purpose of this study was to investigate whether adjuvant radiotherapy (RT) is efficacious for regional control and survival in patients with pN0 oral tongue cancer. METHODS: Clinicopathological features of 166 patients with pN0 oral tongue cancer were compared between those who underwent adjuvant RT to the neck (neck RT-positive) and those who did not (neck RT-negative). Study endpoints were isolated regional recurrence and 3-year regional recurrence-free survival (RRFS). Propensity score matching was also performed. RESULTS: Cox regression analysis did not reveal any significant predictor of isolated regional recurrence, including RT field. Three-year RRFS showed modest improvement in neck RT-positive group compared to neck RT-negative group before (92.2% vs 91.9%) and after propensity analysis (93.8% vs 83.3%), without statistical significance (log-rank P = .85 and .37, respectively). CONCLUSION: Despite more frequent unfavorable factors, the neck RT-positive group had a comparable oncologic outcome to the neck RT-negative group, suggesting that a marginal benefit in regional control might be expected from extending the RT field to the neck for pN0 oral tongue cancer.
Authors: Pencilla Lang; Jessika Contreras; Noah Kalman; Claire Paterson; Houda Bahig; Astrid Billfalk-Kelly; Sinead Brennan; Kathy Rock; Nancy Read; Varagur Venkatesan; Jinka Sathya; Lucas C Mendez; S Danielle MacNeil; Anthony C Nichols; Kevin Fung; Adrian Mendez; Eric Winquist; Sara Kuruvilla; Paul Stewart; Andrew Warner; Sylvia Mitchell; Julie A Theurer; David A Palma Journal: Radiat Oncol Date: 2020-08-14 Impact factor: 3.481