| Literature DB >> 29083001 |
M Urban1, M Franc1, M Hofmanová1, I Císařová2, J Veselý1.
Abstract
An asymmetric organocatalytic addition of fluorinated phenylsulfonylnitromethane to isatin-derived ketimines was developed. The reaction was efficiently catalyzed by a chiral tertiary amine, cinchonine. This methodology provides a new type of optically active compound with two adjacent quaternary carbon stereocenters in good yield (up to 96%), with moderate diastereoselectivity (up to 5.7 : 1 dr) and excellent enantioselectivity (up to 98/96% ee).Entities:
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Year: 2017 PMID： 29083001 DOI： 10.1039/c7ob02408h
Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876