Karina Bilda de Castro Rezende1,2, Antônio José Ledo Alves da Cunha3,4, Cristos Pritsivelis1, Edson Chaves Faleiro1, Joffre Amim Junior1,2, Rita Guérios Bornia1,2. 1. a Maternidade Escola , Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil. 2. b Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil. 3. c Faculdade de Medicina , Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil. 4. d Laboratório Multidisciplinar de Pesquisa em Epidemiologia e Saúde , Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil.
Abstract
Objective: To evaluate the impacts of maternal risk factors described by the Fetal Medicine Foundation's 2012 algorithm (FMF2012) in a Brazilian population. Methods: All singleton pregnancies submitted to first-trimester preeclampsia (PE) screening using the FMF2012 algorithm were considered for study inclusion. Maternal factors, recorded via a patient questionnaire, were described and compared between PE outcome groups. A Gaussian regression model was derived to measure the effects of maternal factors, and to identify factors that contributed significantly (p < .05) to the alteration of gestational age at delivery, in pregnancies with PE. Results: Of the 1934 cases considered for study inclusion, the final sample consisted of 1531 cases. The sample included 120 (7.8%) cases of PE, of which 26 (1.7%) were preterm PE (PE < 37 weeks) and 11 (0.72%) were early PE (PE < 34 weeks). The PE rate did not differ according to ethnicity, smoking, family history of PE, or use of assisted reproductive technology. Significant differences (p < .05) between the normal and PE groups in maternal age, maternal weight, previous history of PE, chronic hypertension, and types 1 and 2 diabetes were detected. Conclusions: The significance and magnitude of associations of maternal factors in our sample differed from those incorporated in the FMF2012 model, implying the need to derive a fitted model for our population.
Objective: To evaluate the impacts of maternal risk factors described by the Fetal Medicine Foundation's 2012 algorithm (FMF2012) in a Brazilian population. Methods: All singleton pregnancies submitted to first-trimester preeclampsia (PE) screening using the FMF2012 algorithm were considered for study inclusion. Maternal factors, recorded via a patient questionnaire, were described and compared between PE outcome groups. A Gaussian regression model was derived to measure the effects of maternal factors, and to identify factors that contributed significantly (p < .05) to the alteration of gestational age at delivery, in pregnancies with PE. Results: Of the 1934 cases considered for study inclusion, the final sample consisted of 1531 cases. The sample included 120 (7.8%) cases of PE, of which 26 (1.7%) were preterm PE (PE < 37 weeks) and 11 (0.72%) were early PE (PE < 34 weeks). The PE rate did not differ according to ethnicity, smoking, family history of PE, or use of assisted reproductive technology. Significant differences (p < .05) between the normal and PE groups in maternal age, maternal weight, previous history of PE, chronic hypertension, and types 1 and 2 diabetes were detected. Conclusions: The significance and magnitude of associations of maternal factors in our sample differed from those incorporated in the FMF2012 model, implying the need to derive a fitted model for our population.
Entities:
Keywords:
First trimester screening; maternal history; preeclampsia; risk factors
Authors: Karina Bilda De Castro Rezende; Antonio José Ledo Alves Cunha; Joffre Amim; Wescule De Moraes Oliveira; Maria Eduarda Belloti Leão; Mariana Oliveira Alves Menezes; Ana Alice Marques Ferraz De Andrade Jardim; Rita Guérios Bornia Journal: J Med Internet Res Date: 2019-11-22 Impact factor: 5.428