| Literature DB >> 29082293 |
Abstract
Pluripotent stem cells in the naïve state are highly useful in regenerative medicine and tissue engineering. A robust reprogramming of the primed murine Epiblast Stem Cells (EpiSCs) to naïve pluripotency is feasible via chemical-only approach. This protocol described a method to reprogram murine EpiSCs by MM-401 treatment, which blocks histone H3K4 methylation by MLL1/KMT2A.Entities:
Keywords: Chemical inhibitor; EpiSCs; H3K4 methylation; MLL1; Naïve pluripotentcy
Year: 2017 PMID： 29082293 PMCID： PMC5659616 DOI： 10.21769/BioProtoc.2168
Source DB: PubMed Journal: Bio Protoc ISSN： 2331-8325