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Literature DB >> 29081989

Platelet count as a predictor of metastasis and venous thromboembolism in patients with cancer.

Joanna L Sylman^1,2,3, Annachiara Mitrugno¹, Garth W Tormoen⁴, Todd H Wagner^2,5, Parag Mallick³, Owen J T McCarty¹.

Abstract

Platelets are anucleate cells in the blood at concentrations of 150,000 to 400,000 cells/µL and play a key role in hemostasis. Several studies have suggested that platelets contribute to cancer progression and cancer-associated thrombosis. In this review, we provide an overview of the biochemical and biophysical mechanisms by which platelets interact with cancer cells and review the evidence supporting a role for platelet-enhanced metastasis of cancer, and venous thromboembolism (VTE) in patients with cancer. We discuss the potential for and limitations of platelet counts to discriminate cancer disease burden and prognosis. Lastly, we consider more advanced diagnostic approaches to improve studies on the interaction between the hemostatic system and cancer cells.

Entities: CellLine Chemical Disease Gene Species

Year: 2017 PMID： 29081989 PMCID： PMC5658139 DOI： 10.1088/2057-1739/aa6c05

Source DB: PubMed Journal: Converg Sci Phys Oncol ISSN： 2057-1739

101 in total

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17 in total

1. Platelet and hemoglobin count at diagnosis are associated with survival in African American and Caucasian patients with colorectal cancer.

Authors: Kristin Wallace; Hong Li; J Grant Brazeal; David N Lewin; Shaoli Sun; Aissatou Ba; Chrystal M Paulos; Saleh Rachidi; Zihai Li; Alexander V Alekseyenko
Journal: Cancer Epidemiol Date: 2020-06-07 Impact factor: 2.984

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Journal: Sci Transl Med Date: 2020-01-08 Impact factor: 17.956